IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease

It is emerging that CD4+Foxp3+ regulatory T (Treg) cells can produce the proinflammatory cytokine IFN-γ when stimulated in a Th1 cytokine environment. In this study, we report that Foxp3+ Treg cells readily produced IFN-γ in vivo in a highly inflammatory model of graft-versus-host disease (GVHD) and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2012-09, Vol.189 (6), p.2890-2896
Hauptverfasser:	Koenecke, Christian, Lee, Chun-Wei, Thamm, Kristina, Föhse, Lisa, Schafferus, Matthias, Mittrücker, Hans-Willi, Floess, Stefan, Huehn, Jochen, Ganser, Arnold, Förster, Reinhold, Prinz, Immo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - transplantation CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cells, Cultured Disease Models, Animal Forkhead Transcription Factors - biosynthesis Graft vs Host Disease - genetics Graft vs Host Disease - immunology Graft vs Host Disease - prevention & control Immunity, Cellular - genetics Interferon-gamma - biosynthesis Interferon-gamma - deficiency Interferon-gamma - secretion Isoantigens - biosynthesis Isoantigens - genetics Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - secretion Th1 Cells - immunology Th1 Cells - pathology Th1 Cells - secretion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!