MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral Myocarditis

RATIONALE:Viral myocarditis results from an adverse immune response to cardiotropic viruses, which causes irreversible myocyte destruction and heart failure in previously healthy people. The involvement of microRNAs and their usefulness as therapeutic targets in this process are unknown. OBJECTIVE:T...

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Veröffentlicht in:	Circulation research 2012-08, Vol.111 (4), p.415-425
Hauptverfasser:	Corsten, Maarten F, Papageorgiou, Anna, Verhesen, Wouter, Carai, Paolo, Lindow, Morten, Obad, Susanna, Summer, Georg, Coort, Susan L.M, Hazebroek, Mark, van Leeuwen, Rick, Gijbels, Marion J.J, Wijnands, Erwin, Biessen, Erik A.L, De Winther, Menno P.J, Stassen, Frank R.M, Carmeliet, Peter, Kauppinen, Sakari, Schroen, Blanche, Heymans, Stephane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Coxsackievirus Coxsackievirus Infections - genetics Coxsackievirus Infections - immunology Coxsackievirus Infections - pathology Coxsackievirus Infections - physiopathology Coxsackievirus Infections - therapy Coxsackievirus Infections - virology Disease Models, Animal Enterovirus B, Human - pathogenicity Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling - methods Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Lymphocyte Activation Macrophages - immunology Macrophages - metabolism Macrophages - virology Medical sciences Mice Mice, Inbred C3H Mice, Inbred C57BL MicroRNAs - metabolism Myocarditis - genetics Myocarditis - immunology Myocarditis - pathology Myocarditis - physiopathology Myocarditis - therapy Myocarditis - virology Myocarditis. Cardiomyopathies Myocardium - immunology Myocardium - metabolism Myocardium - pathology Oligonucleotides - administration & dosage T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - virology Time Factors Vertebrates: cardiovascular system
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