Genome-wide analyses of amphioxus microRNAs reveal an immune regulation via miR-92d targeting C3

Recently, amphioxus has served as a model for studying the origin and evolution of vertebrate immunity. However, little is known about how microRNAs (miRNAs) are involved in the immune defense in amphioxus. In this article, we present a systematic study of amphioxus miRNAs in the acute-phase respons...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-02, Vol.190 (4), p.1491-1500
Hauptverfasser:	Yang, Rirong, Zheng, Tingting, Cai, Xingsheng, Yu, Yingcai, Yu, Cuiling, Guo, Lei, Huang, Shengfeng, Zhu, Wei, Zhu, Ruimin, Yan, Qingyu, Ren, Zhenghua, Chen, Shangwu, Xu, Anlong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - genetics Animals Branchiostoma belcheri Branchiostoma lanceolatum Chordata Chordata, Nonvertebrate - genetics Chordata, Nonvertebrate - immunology Chordata, Nonvertebrate - microbiology Complement C3 - genetics Complement C3 - metabolism Disease Models, Animal Evolution, Molecular Gene Targeting - methods Genome-Wide Association Study - methods HEK293 Cells Humans MicroRNAs - biosynthesis MicroRNAs - genetics MicroRNAs - metabolism Staphylococcal Infections - genetics Staphylococcal Infections - immunology Staphylococcus aureus Vibrio anguillarum Vibrio Infections - genetics Vibrio Infections - immunology
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