Prophylactic total gastrectomy in hereditary diffuse gastric cancer: identification of two novel CDH1 gene mutations—a clinical observational study

Inactivating mutations in the CDH1 (E-cadherin) gene are the predisposing cause of gastric cancer in most families with hereditary diffuse gastric cancer (HDGC). The lifetime risk of cancer in mutation positive members is more than 80 % and prophylactic total gastrectomy is recommended. Not all muta...

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Veröffentlicht in:	Familial cancer 2014-06, Vol.13 (2), p.231-242
Hauptverfasser:	Bardram, Linda, Hansen, Thomas V. O., Gerdes, Anne-Marie, Timshel, Susanne, Friis-Hansen, Lennart, Federspiel, Birgitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedical and Life Sciences Biomedicine Biopsy Cadherins - genetics Cancer Research Computer Simulation DNA Mutational Analysis Epidemiology Female Gastrectomy - adverse effects Gastroscopy Genetic Testing Health Status Human Genetics Humans Male Middle Aged Mutation Original Article Pedigree Risk Assessment Stomach - pathology Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach Neoplasms - prevention & control
Online-Zugang:	Volltext
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