Impact of DaTscan SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use and safety in patients with clinically uncertain parkinsonian syndromes: a prospective 1-year follow-up of an open-label controlled study
BackgroundThis study assessed the impact of DaTscan on clinical management, diagnosis, confidence of diagnosis (CoD), quality of life (QoL), health resource use (HRU) and safety during a 1-year follow-up in patients with clinically uncertain parkinsonian syndromes (CUPS).MethodsA total of 19 univers...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2012-06, Vol.83 (6), p.620-628 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Kupsch, Andreas R Bajaj, Nin Weiland, Frederick Tartaglione, Antonio Klutmann, Susanne Buitendyk, Melanie Sherwin, Paul Tate, Ann Grachev, Igor D |
| description | BackgroundThis study assessed the impact of DaTscan on clinical management, diagnosis, confidence of diagnosis (CoD), quality of life (QoL), health resource use (HRU) and safety during a 1-year follow-up in patients with clinically uncertain parkinsonian syndromes (CUPS).MethodsA total of 19 university hospital centres in Europe and the USA participated in this open-label, single-dose, prospective, clinical trial in patients with CUPS who were randomised to a DaTscan imaging group or to a no-imaging (control) group. The proportion of patients with changes in clinical management, diagnosis, CoD, QoL and HRU from baseline through 1 year post-DaTscan was compared between groups.ResultsThere were 273 patients randomised (135 DaTscan, 138 control). Significantly more patients in the DaTscan imaging group had at least one change in their actual clinical management after 12 weeks (p=0.002) and after 1 year (p |
| doi_str_mv | 10.1136/jnnp-2011-301695 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1551622247</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4023906261</sourcerecordid><originalsourceid>FETCH-LOGICAL-b497t-6bc91ed33f94efc3eafed5e01fde5c63332f81f1e045cfaee9c9ba2b464b8f6f3</originalsourceid><addsrcrecordid>eNqNks1v1DAQxQMC0e3CnROyhJCQ2EBsx8mGG1raUql8SCwf4mI5znjrxXHSOKHkv2fCbgviUqJIkTy_efOceVH0kCbPKeXZi633bcwSSmOe0KwQt6MZTbNlzHny9U40SxLGsCKSg-gwhG0yPcviXnTAWFowRvns1uFp3Srdk8aQ12odtPLk44ej1ZrYWm2s35DGE-2st1o5UiuvNlCD7xeksmrjm2DDgujGG1uB1zDJ_FW4GJSz_TidOmtgQc5Buf6cdBCaoUN8CECUr0hQBpCznrSqt6gfyKVF8GqyG8mA8l2vfiPdd-tD4y2aDaOvuqaG8JIo0nZNaEH39gcQGo-gOmIa55rLeGgnE8g3LfjYqRLcZLvvsAw4vx-q8X501ygX4MH-O48-HR-tV2_is_cnp6tXZ3GZFnkfZ6UuKFScmyIFozmg90pAQk0FQmecc2aW1FBIUqGNAih0USpWpllaLk1m-Dx6utNFuxcDhF7WNmhwTnlohiCpEDRjuKL8ZjShebFMhRD_g7I8LTi-8-jxP-gW1-HxzpLmS4qDEUMq2VEa_2rowMi2w1B0I0rJKX1ySp-c0id36cOWR3vhoayhum64ihsCT_aAwqg50ymvbfjDiUKwlGfIxTvOhh5-Xtdx8TLLeS7ku88rKY6_nKxE-k2-Rf7Zji_r7c02fwFpkgTK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781247934</pqid></control><display><type>article</type><title>Impact of DaTscan SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use and safety in patients with clinically uncertain parkinsonian syndromes: a prospective 1-year follow-up of an open-label controlled study</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Kupsch, Andreas R ; Bajaj, Nin ; Weiland, Frederick ; Tartaglione, Antonio ; Klutmann, Susanne ; Buitendyk, Melanie ; Sherwin, Paul ; Tate, Ann ; Grachev, Igor D</creator><creatorcontrib>Kupsch, Andreas R ; Bajaj, Nin ; Weiland, Frederick ; Tartaglione, Antonio ; Klutmann, Susanne ; Buitendyk, Melanie ; Sherwin, Paul ; Tate, Ann ; Grachev, Igor D</creatorcontrib><description>BackgroundThis study assessed the impact of DaTscan on clinical management, diagnosis, confidence of diagnosis (CoD), quality of life (QoL), health resource use (HRU) and safety during a 1-year follow-up in patients with clinically uncertain parkinsonian syndromes (CUPS).MethodsA total of 19 university hospital centres in Europe and the USA participated in this open-label, single-dose, prospective, clinical trial in patients with CUPS who were randomised to a DaTscan imaging group or to a no-imaging (control) group. The proportion of patients with changes in clinical management, diagnosis, CoD, QoL and HRU from baseline through 1 year post-DaTscan was compared between groups.ResultsThere were 273 patients randomised (135 DaTscan, 138 control). Significantly more patients in the DaTscan imaging group had at least one change in their actual clinical management after 12 weeks (p=0.002) and after 1 year (p<0.001) compared with patients in the control group. In addition, significantly more DaTscan patients had changes in diagnosis and an increased CoD at 4 weeks, 12 weeks and 1 year (all p<0.001) compared with control patients. No significant differences in total score for QoL or HRU were observed between groups during the 1-year follow-up period. DaTscan was safe and well tolerated. One patient in the imaging group had an adverse event (headache) with suspected relationship to DaTscan post-administration.ConclusionsDaTscan had a significant impact on clinical management, diagnosis and CoD in patients with CUPS. DaTscan is safe and well tolerated, and is a useful adjunct to differentiate a diagnosis of CUPS.Trial registration numberhttp://ClinicalTrials.gov Identifier: NCT00382967.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp-2011-301695</identifier><identifier>PMID: 22492213</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alzheimer's disease ; Biological and medical sciences ; clinical ; clinical management ; Clinical medicine ; consciousness ; DaTscan ; dementia ; diagnosis ; Disease Management ; Dopamine ; Female ; Follow-Up Studies ; Humans ; Iodine Radioisotopes ; Male ; Medical sciences ; Middle Aged ; Movement disorders ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; neurophysiology ; neuropsychology ; Nortropanes ; nuclear medicine ; Parkinson's disease ; Parkinsonian Disorders - diagnosis ; Parkinsonian Disorders - diagnostic imaging ; Parkinsonian Disorders - psychology ; parkinsonian syndromes ; Patient Acceptance of Health Care - psychology ; pet ; Predictive Value of Tests ; Prospective Studies ; Quality of life ; Quality of Life - psychology ; Safety - statistics & numerical data ; SPECT ; Tomography, Emission-Computed, Single-Photon - methods ; Tomography, Emission-Computed, Single-Photon - psychology ; Tremor (Muscular contraction)</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2012-06, Vol.83 (6), p.620-628</ispartof><rights>2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2012 (c) 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b497t-6bc91ed33f94efc3eafed5e01fde5c63332f81f1e045cfaee9c9ba2b464b8f6f3</citedby><cites>FETCH-LOGICAL-b497t-6bc91ed33f94efc3eafed5e01fde5c63332f81f1e045cfaee9c9ba2b464b8f6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/83/6/620.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/83/6/620.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77569,77600</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25952436$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22492213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kupsch, Andreas R</creatorcontrib><creatorcontrib>Bajaj, Nin</creatorcontrib><creatorcontrib>Weiland, Frederick</creatorcontrib><creatorcontrib>Tartaglione, Antonio</creatorcontrib><creatorcontrib>Klutmann, Susanne</creatorcontrib><creatorcontrib>Buitendyk, Melanie</creatorcontrib><creatorcontrib>Sherwin, Paul</creatorcontrib><creatorcontrib>Tate, Ann</creatorcontrib><creatorcontrib>Grachev, Igor D</creatorcontrib><title>Impact of DaTscan SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use and safety in patients with clinically uncertain parkinsonian syndromes: a prospective 1-year follow-up of an open-label controlled study</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>BackgroundThis study assessed the impact of DaTscan on clinical management, diagnosis, confidence of diagnosis (CoD), quality of life (QoL), health resource use (HRU) and safety during a 1-year follow-up in patients with clinically uncertain parkinsonian syndromes (CUPS).MethodsA total of 19 university hospital centres in Europe and the USA participated in this open-label, single-dose, prospective, clinical trial in patients with CUPS who were randomised to a DaTscan imaging group or to a no-imaging (control) group. The proportion of patients with changes in clinical management, diagnosis, CoD, QoL and HRU from baseline through 1 year post-DaTscan was compared between groups.ResultsThere were 273 patients randomised (135 DaTscan, 138 control). Significantly more patients in the DaTscan imaging group had at least one change in their actual clinical management after 12 weeks (p=0.002) and after 1 year (p<0.001) compared with patients in the control group. In addition, significantly more DaTscan patients had changes in diagnosis and an increased CoD at 4 weeks, 12 weeks and 1 year (all p<0.001) compared with control patients. No significant differences in total score for QoL or HRU were observed between groups during the 1-year follow-up period. DaTscan was safe and well tolerated. One patient in the imaging group had an adverse event (headache) with suspected relationship to DaTscan post-administration.ConclusionsDaTscan had a significant impact on clinical management, diagnosis and CoD in patients with CUPS. DaTscan is safe and well tolerated, and is a useful adjunct to differentiate a diagnosis of CUPS.Trial registration numberhttp://ClinicalTrials.gov Identifier: NCT00382967.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>clinical</subject><subject>clinical management</subject><subject>Clinical medicine</subject><subject>consciousness</subject><subject>DaTscan</subject><subject>dementia</subject><subject>diagnosis</subject><subject>Disease Management</subject><subject>Dopamine</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>neurophysiology</subject><subject>neuropsychology</subject><subject>Nortropanes</subject><subject>nuclear medicine</subject><subject>Parkinson's disease</subject><subject>Parkinsonian Disorders - diagnosis</subject><subject>Parkinsonian Disorders - diagnostic imaging</subject><subject>Parkinsonian Disorders - psychology</subject><subject>parkinsonian syndromes</subject><subject>Patient Acceptance of Health Care - psychology</subject><subject>pet</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Safety - statistics & numerical data</subject><subject>SPECT</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><subject>Tomography, Emission-Computed, Single-Photon - psychology</subject><subject>Tremor (Muscular contraction)</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks1v1DAQxQMC0e3CnROyhJCQ2EBsx8mGG1raUql8SCwf4mI5znjrxXHSOKHkv2fCbgviUqJIkTy_efOceVH0kCbPKeXZi633bcwSSmOe0KwQt6MZTbNlzHny9U40SxLGsCKSg-gwhG0yPcviXnTAWFowRvns1uFp3Srdk8aQ12odtPLk44ej1ZrYWm2s35DGE-2st1o5UiuvNlCD7xeksmrjm2DDgujGG1uB1zDJ_FW4GJSz_TidOmtgQc5Buf6cdBCaoUN8CECUr0hQBpCznrSqt6gfyKVF8GqyG8mA8l2vfiPdd-tD4y2aDaOvuqaG8JIo0nZNaEH39gcQGo-gOmIa55rLeGgnE8g3LfjYqRLcZLvvsAw4vx-q8X501ygX4MH-O48-HR-tV2_is_cnp6tXZ3GZFnkfZ6UuKFScmyIFozmg90pAQk0FQmecc2aW1FBIUqGNAih0USpWpllaLk1m-Dx6utNFuxcDhF7WNmhwTnlohiCpEDRjuKL8ZjShebFMhRD_g7I8LTi-8-jxP-gW1-HxzpLmS4qDEUMq2VEa_2rowMi2w1B0I0rJKX1ySp-c0id36cOWR3vhoayhum64ihsCT_aAwqg50ymvbfjDiUKwlGfIxTvOhh5-Xtdx8TLLeS7ku88rKY6_nKxE-k2-Rf7Zji_r7c02fwFpkgTK</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Kupsch, Andreas R</creator><creator>Bajaj, Nin</creator><creator>Weiland, Frederick</creator><creator>Tartaglione, Antonio</creator><creator>Klutmann, Susanne</creator><creator>Buitendyk, Melanie</creator><creator>Sherwin, Paul</creator><creator>Tate, Ann</creator><creator>Grachev, Igor D</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T2</scope><scope>7TK</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20120601</creationdate><title>Impact of DaTscan SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use and safety in patients with clinically uncertain parkinsonian syndromes: a prospective 1-year follow-up of an open-label controlled study</title><author>Kupsch, Andreas R ; Bajaj, Nin ; Weiland, Frederick ; Tartaglione, Antonio ; Klutmann, Susanne ; Buitendyk, Melanie ; Sherwin, Paul ; Tate, Ann ; Grachev, Igor D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b497t-6bc91ed33f94efc3eafed5e01fde5c63332f81f1e045cfaee9c9ba2b464b8f6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>clinical</topic><topic>clinical management</topic><topic>Clinical medicine</topic><topic>consciousness</topic><topic>DaTscan</topic><topic>dementia</topic><topic>diagnosis</topic><topic>Disease Management</topic><topic>Dopamine</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>neurophysiology</topic><topic>neuropsychology</topic><topic>Nortropanes</topic><topic>nuclear medicine</topic><topic>Parkinson's disease</topic><topic>Parkinsonian Disorders - diagnosis</topic><topic>Parkinsonian Disorders - diagnostic imaging</topic><topic>Parkinsonian Disorders - psychology</topic><topic>parkinsonian syndromes</topic><topic>Patient Acceptance of Health Care - psychology</topic><topic>pet</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Safety - statistics & numerical data</topic><topic>SPECT</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><topic>Tomography, Emission-Computed, Single-Photon - psychology</topic><topic>Tremor (Muscular contraction)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kupsch, Andreas R</creatorcontrib><creatorcontrib>Bajaj, Nin</creatorcontrib><creatorcontrib>Weiland, Frederick</creatorcontrib><creatorcontrib>Tartaglione, Antonio</creatorcontrib><creatorcontrib>Klutmann, Susanne</creatorcontrib><creatorcontrib>Buitendyk, Melanie</creatorcontrib><creatorcontrib>Sherwin, Paul</creatorcontrib><creatorcontrib>Tate, Ann</creatorcontrib><creatorcontrib>Grachev, Igor D</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kupsch, Andreas R</au><au>Bajaj, Nin</au><au>Weiland, Frederick</au><au>Tartaglione, Antonio</au><au>Klutmann, Susanne</au><au>Buitendyk, Melanie</au><au>Sherwin, Paul</au><au>Tate, Ann</au><au>Grachev, Igor D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of DaTscan SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use and safety in patients with clinically uncertain parkinsonian syndromes: a prospective 1-year follow-up of an open-label controlled study</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>83</volume><issue>6</issue><spage>620</spage><epage>628</epage><pages>620-628</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>BackgroundThis study assessed the impact of DaTscan on clinical management, diagnosis, confidence of diagnosis (CoD), quality of life (QoL), health resource use (HRU) and safety during a 1-year follow-up in patients with clinically uncertain parkinsonian syndromes (CUPS).MethodsA total of 19 university hospital centres in Europe and the USA participated in this open-label, single-dose, prospective, clinical trial in patients with CUPS who were randomised to a DaTscan imaging group or to a no-imaging (control) group. The proportion of patients with changes in clinical management, diagnosis, CoD, QoL and HRU from baseline through 1 year post-DaTscan was compared between groups.ResultsThere were 273 patients randomised (135 DaTscan, 138 control). Significantly more patients in the DaTscan imaging group had at least one change in their actual clinical management after 12 weeks (p=0.002) and after 1 year (p<0.001) compared with patients in the control group. In addition, significantly more DaTscan patients had changes in diagnosis and an increased CoD at 4 weeks, 12 weeks and 1 year (all p<0.001) compared with control patients. No significant differences in total score for QoL or HRU were observed between groups during the 1-year follow-up period. DaTscan was safe and well tolerated. One patient in the imaging group had an adverse event (headache) with suspected relationship to DaTscan post-administration.ConclusionsDaTscan had a significant impact on clinical management, diagnosis and CoD in patients with CUPS. DaTscan is safe and well tolerated, and is a useful adjunct to differentiate a diagnosis of CUPS.Trial registration numberhttp://ClinicalTrials.gov Identifier: NCT00382967.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>22492213</pmid><doi>10.1136/jnnp-2011-301695</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 2012-06, Vol.83 (6), p.620-628 |
| issn | 0022-3050 1468-330X |
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| subjects | Adult Aged Aged, 80 and over Alzheimer's disease Biological and medical sciences clinical clinical management Clinical medicine consciousness DaTscan dementia diagnosis Disease Management Dopamine Female Follow-Up Studies Humans Iodine Radioisotopes Male Medical sciences Middle Aged Movement disorders Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology neurophysiology neuropsychology Nortropanes nuclear medicine Parkinson's disease Parkinsonian Disorders - diagnosis Parkinsonian Disorders - diagnostic imaging Parkinsonian Disorders - psychology parkinsonian syndromes Patient Acceptance of Health Care - psychology pet Predictive Value of Tests Prospective Studies Quality of life Quality of Life - psychology Safety - statistics & numerical data SPECT Tomography, Emission-Computed, Single-Photon - methods Tomography, Emission-Computed, Single-Photon - psychology Tremor (Muscular contraction) |
| title | Impact of DaTscan SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use and safety in patients with clinically uncertain parkinsonian syndromes: a prospective 1-year follow-up of an open-label controlled study |
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