Foxp3 expression is required for the induction of therapeutic tissue tolerance

CD4(+)Foxp3(+) regulatory T cells (Treg) are essential for immune homeostasis and maintenance of self-tolerance. They are produced in the thymus and also generated de novo in the periphery in a TGF-β-dependent manner. Foxp3(+) Treg are also required to achieve tolerance to transplanted tissues when...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-10, Vol.189 (8), p.3947-3956
Hauptverfasser:	Regateiro, Frederico S, Chen, Ye, Kendal, Adrian R, Hilbrands, Robert, Adams, Elizabeth, Cobbold, Stephen P, Ma, Jianbo, Andersen, Kristian G, Betz, Alexander G, Zhang, Mindy, Madhiwalla, Shruti, Roberts, Bruce, Waldmann, Herman, Nolan, Kathleen F, Howie, Duncan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Forkhead Transcription Factors - biosynthesis Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - genetics Graft Survival - genetics Graft Survival - immunology Humans Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout Mice, Transgenic Signal Transduction - genetics Signal Transduction - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - physiology Transplantation Tolerance - genetics
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