Cell cycle regulates cell type in the Arabidopsis sepal
The formation of cellular patterns during development requires the coordination of cell division with cell identity specification. This coordination is essential in patterning the highly elongated giant cells, which are interspersed between small cells, in the outer epidermis of the Arabidopsis thal...
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| Veröffentlicht in: | Development (Cambridge) 2012-12, Vol.139 (23), p.4416-4427 |
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| container_title | Development (Cambridge) |
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| creator | Roeder, Adrienne H K Cunha, Alexandre Ohno, Carolyn K Meyerowitz, Elliot M |
| description | The formation of cellular patterns during development requires the coordination of cell division with cell identity specification. This coordination is essential in patterning the highly elongated giant cells, which are interspersed between small cells, in the outer epidermis of the Arabidopsis thaliana sepal. Giant cells undergo endocycles, replicating their DNA without dividing, whereas small cells divide mitotically. We show that distinct enhancers are expressed in giant cells and small cells, indicating that these cell types have different identities as well as different sizes. We find that members of the epidermal specification pathway, DEFECTIVE KERNEL1 (DEK1), MERISTEM LAYER1 (ATML1), Arabidopsis CRINKLY4 (ACR4) and HOMEODOMAIN GLABROUS11 (HDG11), control the identity of giant cells. Giant cell identity is established upstream of cell cycle regulation. Conversely, endoreduplication represses small cell identity. These results show not only that cell type affects cell cycle regulation, but also that changes in the cell cycle can regulate cell type. |
| doi_str_mv | 10.1242/dev.082925 |
| format | Article |
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This coordination is essential in patterning the highly elongated giant cells, which are interspersed between small cells, in the outer epidermis of the Arabidopsis thaliana sepal. Giant cells undergo endocycles, replicating their DNA without dividing, whereas small cells divide mitotically. We show that distinct enhancers are expressed in giant cells and small cells, indicating that these cell types have different identities as well as different sizes. We find that members of the epidermal specification pathway, DEFECTIVE KERNEL1 (DEK1), MERISTEM LAYER1 (ATML1), Arabidopsis CRINKLY4 (ACR4) and HOMEODOMAIN GLABROUS11 (HDG11), control the identity of giant cells. Giant cell identity is established upstream of cell cycle regulation. Conversely, endoreduplication represses small cell identity. 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| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2012-12, Vol.139 (23), p.4416-4427 |
| issn | 0950-1991 1477-9129 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Arabidopsis - cytology Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana Calpain - genetics Calpain - metabolism Cell Cycle Cell Differentiation Cell Division DNA Replication Endoreduplication - genetics Flowers - cytology Flowers - genetics Gene Expression Regulation, Developmental Gene Expression Regulation, Plant Genotype Giant Cells Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Morphogenesis Mutation Plant Epidermis - cytology Plant Epidermis - genetics Plants, Genetically Modified Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism |
| title | Cell cycle regulates cell type in the Arabidopsis sepal |
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