Cathepsin B controls the persistence of memory CD8+ T lymphocytes

The persistence of memory T lymphocytes confers lifelong protection from pathogens. Memory T cells survive and undergo homeostatic proliferation (HSP) in the absence of Ag, although the cell-intrinsic mechanisms by which cytokines drive the HSP of memory T cells are not well understood. In this stud...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-08, Vol.189 (3), p.1133-1143
Hauptverfasser:	Byrne, Susan M, Aucher, Anne, Alyahya, Syarifah, Elder, Matthew, Olson, Steven T, Davis, Daniel M, Ashton-Rickardt, Philip G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cathepsin B - antagonists & inhibitors Cathepsin B - genetics Cathepsin B - physiology CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Cell Proliferation Cell Survival - genetics Cell Survival - immunology Female Homeostasis - genetics Homeostasis - immunology Immunologic Memory - genetics Lymphocytic choriomeningitis virus Lysosomes - enzymology Lysosomes - immunology Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Mice, Transgenic Serpins - deficiency Serpins - physiology
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