Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells

The Runx1 transcription factor is abundantly expressed in naive T cells but rapidly downregulated in activated T cells, suggesting that it plays an important role in a naive stage. In the current study, Runx1(-/-)Bcl2(tg) mice harboring Runx1-deleted CD4(+) T cells developed a fatal autoimmune lung...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-06, Vol.188 (11), p.5408-5420
Hauptverfasser:	Wong, Won Fen, Kohu, Kazuyoshi, Nakamura, Akira, Ebina, Masahito, Kikuchi, Toshiaki, Tazawa, Ryushi, Tanaka, Keisuke, Kon, Shunsuke, Funaki, Tomo, Sugahara-Tobinai, Akiko, Looi, Chung Yeng, Endo, Shota, Funayama, Ryo, Kurokawa, Mineo, Habu, Sonoko, Ishii, Naoto, Fukumoto, Manabu, Nakata, Koh, Takai, Toshiyuki, Satake, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - immunology Autoimmune Diseases - mortality Autoimmune Diseases - pathology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Core Binding Factor Alpha 2 Subunit - deficiency Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - physiology Cytokines - antagonists & inhibitors Cytokines - genetics Humans Inflammation - genetics Inflammation - immunology Inflammation - mortality Jurkat Cells Lung Diseases - immunology Lung Diseases - mortality Lung Diseases - pathology Lymphocyte Activation - genetics Lymphocyte Activation - immunology Mice Mice, Transgenic Pulmonary Alveoli - immunology Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology
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