FLT-PET Is Superior to FDG-PET for Very Early Response Prediction in NPM-ALK-Positive Lymphoma Treated with Targeted Therapy

The prognosis of relapsed or refractory aggressive lymphoma is poor. The huge variety of currently evolving targeted treatment approaches would benefit from tools for early prediction of response or resistance. We used various ALK-positive anaplastic large cell lymphoma (ALCL) cell lines to evaluate...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-10, Vol.72 (19), p.5014-5024
Hauptverfasser:	ZHOULEI LI, GRAF, Nicolas, BUCK, Andreas, KELLER, Ulrich, DECHOW, Tobias, HERRMANN, Ken, JÜNGER, Alexandra, AICHLER, Michaela, FEUCHTINGER, Annette, BAUMGART, Anja, WALCH, Axel, PESCHEL, Christian, SCHWAIGER, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Blotting, Western Cell Line Cell Line, Tumor Cell Survival - drug effects Chromosome aberrations Dideoxynucleosides Enzyme Inhibitors - pharmacology Everolimus Female Flow Cytometry Fluorine Radioisotopes Fluorodeoxyglucose F18 HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Humans Isoxazoles - pharmacology Lymphoma, Large-Cell, Anaplastic - diagnostic imaging Lymphoma, Large-Cell, Anaplastic - drug therapy Lymphoma, Large-Cell, Anaplastic - pathology Medical genetics Medical sciences Mice Mice, SCID Pharmacology. Drug treatments Positron-Emission Tomography - methods Protein-Tyrosine Kinases - metabolism Resorcinols - pharmacology Sirolimus - analogs & derivatives Sirolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Treatment Outcome Tumor Burden - drug effects Tumors Xenograft Model Antitumor Assays
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