MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells

HSC fate decisions are regulated by cell-intrinsic and cell-extrinsic cues. The latter cues are derived from the BM niche. Membrane-type 1 matrix metalloproteinase (MT1-MMP), which is best known for its proteolytic role in pericellular matrix remodeling, is highly expressed in HSCs and stromal/niche...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2012-06, Vol.119 (23), p.5405-5416
Hauptverfasser:	Nishida, Chiemi, Kusubata, Kaori, Tashiro, Yoshihiko, Gritli, Ismael, Sato, Aki, Ohki-Koizumi, Makiko, Morita, Yohei, Nagano, Makoto, Sakamoto, Takeharu, Koshikawa, Naohiko, Kuchimaru, Takahiro, Kizaka-Kondoh, Shinae, Seiki, Motoharu, Nakauchi, Hiromitsu, Heissig, Beate, Hattori, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - metabolism Biological and medical sciences Cell Line Cells, Cultured Chemokine CXCL12 - metabolism Chemokines - genetics Cytokines - genetics Erythroid Cells - cytology Erythroid Cells - metabolism Gene Deletion Hematologic and hematopoietic diseases Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Hypoxia-Inducible Factor 1 - metabolism Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Medical sciences Mice Mice, Inbred C57BL Stem Cell Factor - metabolism Stromal Cells - cytology Stromal Cells - metabolism T-Lymphocytes - cytology T-Lymphocytes - metabolism Transcriptional Activation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!