PTPN22 alters the development of regulatory T cells in the thymus

PTPN22 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling in lymphocytes and is strongly linked with susceptibility to a number of autoimmune diseases. As strength of TCR signal is critical to the thymic selection of regulatory T cells (Tregs), we e...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2012-06, Vol.188 (11), p.5267-5275
Hauptverfasser:	Maine, Christian J, Hamilton-Williams, Emma E, Cheung, Jocelyn, Stanford, Stephanie M, Bottini, Nunzio, Wicker, Linda S, Sherman, Linda A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Encephalomyelitis, Autoimmune, Experimental - enzymology Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Female Mice Mice, Inbred C57BL Mice, Knockout Multiple Sclerosis - immunology Multiple Sclerosis - pathology Protein Tyrosine Phosphatase, Non-Receptor Type 22 - biosynthesis Protein Tyrosine Phosphatase, Non-Receptor Type 22 - deficiency Protein Tyrosine Phosphatase, Non-Receptor Type 22 - physiology T-Lymphocytes, Regulatory - enzymology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Thymus Gland - enzymology Thymus Gland - immunology Thymus Gland - pathology Up-Regulation - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!