Protein Kinase C-{theta} Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a-Dependent Pathway

Protein kinase C (PKC)-{theta} has been shown to be a critical TCR signaling molecule that promotes the activation and differentiation of naive T cells into inflammatory effector T cells. In this study, we demonstrate that PKC-{theta}-mediated signals inhibit inducible regulatory T cell (iTreg) diff...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-06, Vol.188 (11), p.5337-5347
Hauptverfasser:	Ma, Jian, Ding, Yan, Fang, Xianfeng, Wang, Ruiqing, Sun, Zuoming
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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