TLR15 is unique to avian and reptilian lineages and recognizes a yeast-derived agonist

The TLRs represent a family of pattern recognition receptors critical in the induction of vertebrate immune responses. Between 10 and 13 different TLR genes can be identified in each vertebrate species, with many represented as orthologous genes in different species. The agonist specificity of ortho...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-11, Vol.189 (10), p.4930-4938
Hauptverfasser:	Boyd, Amy C, Peroval, Marylene Y, Hammond, John A, Prickett, Michael D, Young, John R, Smith, Adrian L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Fungal - chemistry Antigens, Fungal - immunology Avian Proteins - genetics Avian Proteins - immunology Birds - genetics Birds - immunology Candida albicans Evolution, Molecular HEK293 Cells Humans Interleukin-1beta - genetics Interleukin-1beta - immunology Lizards - genetics Lizards - immunology NF-kappa B - genetics NF-kappa B - immunology Saccharomyces cerevisiae Schizosaccharomyces pombe Signal Transduction - physiology Species Specificity Toll-Like Receptors - agonists Toll-Like Receptors - genetics Toll-Like Receptors - immunology Yeasts - chemistry Yeasts - immunology
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