Cognitive domain deficits in patients with aneurysmal subarachnoid haemorrhage at 1year

BackgroundCognitive domain deficits can occur after aneurysmal subarachnoid haemorrhage (aSAH) though few studies systemically evaluate its impact on 1-year outcomes.ObjectiveWe aimed to evaluate the pattern and functional outcome impact of cognitive domain deficits in aSAH patients at 1year.MethodsWe carried out a prospective observational study in Hong Kong, during which, 168 aSAH patients (aged 21-75years and had been admitted within 96h of ictus) were recruited over a 26-month period. The cognitive function was assessed by a domain-specific neuropsychological assessment battery at 1year after ictus. The current study is registered at ClinicalTrials.gov of the US National Institutes of Health (NCT01038193).ResultsPrevalence of individual domain deficits varied between 7% to 15%, and 13% had two or more domain deficits. After adjusting for abbreviated National Institute of Health Stroke Scale and Geriatric Depressive Scale scores, unfavourable outcome (Modified Rankin Scale 3-5) and dependent instrumental activity of daily living (Lawton Instrumental Activity of Daily Living