Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections

Respiratory tract infection with Pseudomonas aeruginosa is a common cause of hospitalization in immune-compromised individuals. However, the molecular mechanisms involved in the immune response to P. aeruginosa lung infection remain incompletely defined. In this study, we demonstrate that the regula...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-05, Vol.190 (10), p.5178-5186
Hauptverfasser:	Junkins, Robert D, MacNeil, Adam J, Wu, Zhengli, McCormick, Craig, Lin, Tong-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Load Calcineurin - metabolism Cytokines - blood Extracellular Signal-Regulated MAP Kinases - metabolism Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Macrophages - immunology Mice Mice, Inbred C57BL Muscle Proteins - deficiency Muscle Proteins - genetics Muscle Proteins - metabolism Neutrophil Infiltration Neutrophils - immunology NF-kappa B - biosynthesis NF-kappa B - genetics NFATC Transcription Factors - biosynthesis NFATC Transcription Factors - genetics Pneumonia, Bacterial - immunology Pneumonia, Bacterial - microbiology Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Pseudomonas Infections - immunology Pseudomonas Infections - microbiology STAT3 Transcription Factor - metabolism
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