CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy

CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. The objective...

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Veröffentlicht in:	Blood 2013-01, Vol.121 (1), p.129-135
Hauptverfasser:	Nevo, Yoram, Ben-Zeev, Bruria, Tabib, Adi, Straussberg, Rachel, Anikster, Yair, Shorer, Zamir, Fattal-Valevski, Aviva, Ta-Shma, Asaf, Aharoni, Sharon, Rabie, Malcolm, Zenvirt, Shamir, Goldshmidt, Hanoch, Fellig, Yakov, Shaag, Avraham, Mevorach, Dror, Elpeleg, Orly
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Amino Acid Sequence Anemia, Hemolytic - blood Anemia, Hemolytic - cerebrospinal fluid Anemia, Hemolytic - ethnology Anemia, Hemolytic - genetics Biological and medical sciences CD59 Antigens - genetics CD59 Antigens - metabolism Child, Preschool Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Female Founder Effect Hematologic and hematopoietic diseases Hemoglobinuria - blood Hemoglobinuria - cerebrospinal fluid Hemoglobinuria - ethnology Hemoglobinuria - genetics Humans Infant Jews - genetics Libya - ethnology Male Medical sciences Membrane Proteins - analysis Molecular Sequence Data Morocco - ethnology Mutation, Missense Nervous system (semeiology, syndromes) Neurology Pedigree Point Mutation Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - blood Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - cerebrospinal fluid Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - ethnology Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - genetics Protein Transport
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