Biomarkers in psoriasis and psoriatic arthritis
Psoriasis is a common immune-mediated disease of the skin, which associates in 20–30% of patients with psoriatic arthritis (PsA). The immunopathogenesis of both conditions is not fully understood as it is the result of a complex interaction between genetic, environmental and immunological factors. A...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2013-04, Vol.72 (suppl 2), p.ii104-ii110 |
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| container_issue | suppl 2 |
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| container_title | Annals of the rheumatic diseases |
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| creator | Villanova, Federica Di Meglio, Paola Nestle, Frank O |
| description | Psoriasis is a common immune-mediated disease of the skin, which associates in 20–30% of patients with psoriatic arthritis (PsA). The immunopathogenesis of both conditions is not fully understood as it is the result of a complex interaction between genetic, environmental and immunological factors. At present there is no cure for psoriasis and there are no specific markers that can accurately predict disease progression and therapeutic response. Therefore, biomarkers for disease prognosis and response to treatment are urgently needed to help clinicians with objective indications to improve patient management and outcomes. Although many efforts have been made to identify psoriasis/PsA biomarkers none of them has yet been translated into routine clinical practice. In this review we summarise the different classes of possible biomarkers explored in psoriasis and PsA so far and discuss novel strategies for biomarker discovery. |
| doi_str_mv | 10.1136/annrheumdis-2012-203037 |
| format | Article |
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The immunopathogenesis of both conditions is not fully understood as it is the result of a complex interaction between genetic, environmental and immunological factors. At present there is no cure for psoriasis and there are no specific markers that can accurately predict disease progression and therapeutic response. Therefore, biomarkers for disease prognosis and response to treatment are urgently needed to help clinicians with objective indications to improve patient management and outcomes. Although many efforts have been made to identify psoriasis/PsA biomarkers none of them has yet been translated into routine clinical practice. In this review we summarise the different classes of possible biomarkers explored in psoriasis and PsA so far and discuss novel strategies for biomarker discovery.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2012-203037</identifier><identifier>PMID: 23532439</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Arthritis ; Arthritis, Psoriatic - blood ; Arthritis, Psoriatic - genetics ; Arthritis, Psoriatic - metabolism ; Bioinformatics ; Biomarkers ; Biomarkers - blood ; Biomarkers - metabolism ; Cardiovascular disease ; Cytokines ; Gene expression ; Genetic Markers ; Humans ; Immunology ; Immunotherapy ; Inflammation ; Inflammatory diseases ; Medical diagnosis ; Patients ; Proteins ; Psoriasis ; Psoriasis - blood ; Psoriasis - genetics ; Psoriasis - metabolism ; Psoriatic Arthritis ; TNF-alpha ; Treatment ; Tumor necrosis factor-TNF</subject><ispartof>Annals of the rheumatic diseases, 2013-04, Vol.72 (suppl 2), p.ii104-ii110</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2013 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b481t-a44d77fb74b29e2fb37d28f6297934f71b99ec93ab92153aa75d39d6dea0180e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/72/suppl_2/ii104.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/72/suppl_2/ii104.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23532439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villanova, Federica</creatorcontrib><creatorcontrib>Di Meglio, Paola</creatorcontrib><creatorcontrib>Nestle, Frank O</creatorcontrib><title>Biomarkers in psoriasis and psoriatic arthritis</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Psoriasis is a common immune-mediated disease of the skin, which associates in 20–30% of patients with psoriatic arthritis (PsA). The immunopathogenesis of both conditions is not fully understood as it is the result of a complex interaction between genetic, environmental and immunological factors. At present there is no cure for psoriasis and there are no specific markers that can accurately predict disease progression and therapeutic response. Therefore, biomarkers for disease prognosis and response to treatment are urgently needed to help clinicians with objective indications to improve patient management and outcomes. Although many efforts have been made to identify psoriasis/PsA biomarkers none of them has yet been translated into routine clinical practice. In this review we summarise the different classes of possible biomarkers explored in psoriasis and PsA so far and discuss novel strategies for biomarker discovery.</description><subject>Arthritis</subject><subject>Arthritis, Psoriatic - blood</subject><subject>Arthritis, Psoriatic - genetics</subject><subject>Arthritis, Psoriatic - metabolism</subject><subject>Bioinformatics</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cytokines</subject><subject>Gene expression</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Medical diagnosis</subject><subject>Patients</subject><subject>Proteins</subject><subject>Psoriasis</subject><subject>Psoriasis - blood</subject><subject>Psoriasis - genetics</subject><subject>Psoriasis - metabolism</subject><subject>Psoriatic Arthritis</subject><subject>TNF-alpha</subject><subject>Treatment</subject><subject>Tumor necrosis factor-TNF</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1PxCAQhonR6Lr6F3QTL16qwFAGjrrxM0YvarwRuqWRdduu0Cb678V0NcaLXiBv5pkJPEPIPqNHjIE8tk0Tnl1flz5mnDKeDqCAa2TEhFQpSbpORpRSyISWuEW2Y5ynSBVTm2SLQw5cgB6R41Pf1ja8uBAnvpksYxu8jT5ObFOuUudnExu65-A7H3fIRmUX0e2u7jF5OD-7n15mN3cXV9OTm6wQinWZFaJErAoUBdeOVwVgyVUluUYNokJWaO1mGmyhOcvBWsxL0KUsnaVMUQdjcjjMXYb2tXexM7WPM7dY2Ma1fTQsz5lkuUb4GwUOHBVLisbk4Bc6b_vQpI8YhohKCUl5onCgZqGNMbjKLINPkt4No-ZTv_mh33zqN4P-1Lm3mt8XtSu_-758JyAbAB879_ZdTwswEgFzc_s4Nden_Enfnj-Zi8TzgS_q-b9f8QEhaqGv</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Villanova, Federica</creator><creator>Di Meglio, Paola</creator><creator>Nestle, Frank O</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130401</creationdate><title>Biomarkers in psoriasis and psoriatic arthritis</title><author>Villanova, Federica ; Di Meglio, Paola ; Nestle, Frank O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b481t-a44d77fb74b29e2fb37d28f6297934f71b99ec93ab92153aa75d39d6dea0180e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Arthritis</topic><topic>Arthritis, Psoriatic - blood</topic><topic>Arthritis, Psoriatic - genetics</topic><topic>Arthritis, Psoriatic - metabolism</topic><topic>Bioinformatics</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cytokines</topic><topic>Gene expression</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Immunology</topic><topic>Immunotherapy</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Medical diagnosis</topic><topic>Patients</topic><topic>Proteins</topic><topic>Psoriasis</topic><topic>Psoriasis - blood</topic><topic>Psoriasis - genetics</topic><topic>Psoriasis - metabolism</topic><topic>Psoriatic Arthritis</topic><topic>TNF-alpha</topic><topic>Treatment</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villanova, Federica</creatorcontrib><creatorcontrib>Di Meglio, Paola</creatorcontrib><creatorcontrib>Nestle, Frank O</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villanova, Federica</au><au>Di Meglio, Paola</au><au>Nestle, Frank O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers in psoriasis and psoriatic arthritis</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>72</volume><issue>suppl 2</issue><spage>ii104</spage><epage>ii110</epage><pages>ii104-ii110</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Psoriasis is a common immune-mediated disease of the skin, which associates in 20–30% of patients with psoriatic arthritis (PsA). The immunopathogenesis of both conditions is not fully understood as it is the result of a complex interaction between genetic, environmental and immunological factors. At present there is no cure for psoriasis and there are no specific markers that can accurately predict disease progression and therapeutic response. Therefore, biomarkers for disease prognosis and response to treatment are urgently needed to help clinicians with objective indications to improve patient management and outcomes. Although many efforts have been made to identify psoriasis/PsA biomarkers none of them has yet been translated into routine clinical practice. In this review we summarise the different classes of possible biomarkers explored in psoriasis and PsA so far and discuss novel strategies for biomarker discovery.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>23532439</pmid><doi>10.1136/annrheumdis-2012-203037</doi></addata></record> |
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| ispartof | Annals of the rheumatic diseases, 2013-04, Vol.72 (suppl 2), p.ii104-ii110 |
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| subjects | Arthritis Arthritis, Psoriatic - blood Arthritis, Psoriatic - genetics Arthritis, Psoriatic - metabolism Bioinformatics Biomarkers Biomarkers - blood Biomarkers - metabolism Cardiovascular disease Cytokines Gene expression Genetic Markers Humans Immunology Immunotherapy Inflammation Inflammatory diseases Medical diagnosis Patients Proteins Psoriasis Psoriasis - blood Psoriasis - genetics Psoriasis - metabolism Psoriatic Arthritis TNF-alpha Treatment Tumor necrosis factor-TNF |
| title | Biomarkers in psoriasis and psoriatic arthritis |
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