In vitro cytotoxicity and antiviral efficacy against feline herpesvirus type 1 of famciclovir and its metabolites

OBJECTIVES: To assess in vitro the antiviral efficacy against feline herpesvirus (FHV‐1) and cytotoxicity for cultured feline cells of famciclovir and its metabolites, BRL 42359 and penciclovir. To investigate the effect of timing of penciclovir application on in vitro antiviral activity. PROCEDURES...

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Veröffentlicht in:	Veterinary ophthalmology 2014-07, Vol.17 (4), p.268-274
Hauptverfasser:	Groth, Allyson D, Contreras, Marcos T, Kado‐Fong, Helen K, Nguyen, Kyvan Q, Thomasy, Sara M, Maggs, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine - analogs & derivatives 2-Aminopurine - pharmacology Acyclovir - analogs & derivatives Acyclovir - pharmacology adsorption Animals Antiviral Agents - pharmacology antiviral drugs antiviral properties cat Cats cell biology Cell Line cytotoxicity Dose-Response Relationship, Drug Felid herpesvirus 1 Herpesviridae - classification Herpesvirus herpetic disease Inhibitory Concentration 50 metabolites penciclovir Viral Plaque Assay - veterinary virology
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