Identification of pancreatic glycoprotein 2 as an endogenous immunomodulator of innate and adaptive immune responses

Pancreatic autoantibodies are Crohn disease-specific serologic markers. The function and immunological role of their recently identified autoantigen, glycoprotein 2 (GP2), are unknown. We therefore investigated the impact of GP2 on modulation of innate and adaptive immune responses to evaluate its p...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-09, Vol.189 (6), p.2774-2783
Hauptverfasser:	Werner, Lael, Paclik, Daniela, Fritz, Christina, Reinhold, Dirk, Roggenbuck, Dirk, Sturm, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Autoantigens - physiology Cell Line Cells, Cultured Colitis, Ulcerative - immunology Colitis, Ulcerative - therapy Crohn Disease - immunology Crohn Disease - therapy GPI-Linked Proteins - physiology Humans Immunity, Innate Immunologic Factors - physiology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism
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