Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells

After an exposure to ionising radiation, cells can quickly repair damage to their genomes; however, a few unrepairable DNA double-strand breaks (DSBs) emerge in the nucleus in a prolonged culture and perpetuate as long as the culture continues. These DSBs may be retained forever in cells such as non...

Ausführliche Beschreibung