Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18

Keratin 1 (KRT1) and its heterodimer partner keratin 10 (KRT10) are major constituents of the intermediate filament cytoskeleton in suprabasal epidermis. KRT1 mutations cause epidermolytic ichthyosis in humans, characterized by loss of barrier integrity and recurrent erythema. In search of the large...

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Veröffentlicht in:	Journal of cell science 2012-11, Vol.125 (Pt 22), p.5269-5279
Hauptverfasser:	Roth, Wera, Kumar, Vinod, Beer, Hans-Dietmar, Richter, Miriam, Wohlenberg, Claudia, Reuter, Ursula, Thiering, Sören, Staratschek-Jox, Andrea, Hofmann, Andrea, Kreusch, Fatima, Schultze, Joachim L, Vogl, Thomas, Roth, Johannes, Reichelt, Julia, Hausser, Ingrid, Magin, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caspase 1 - metabolism Cell Differentiation Desmosomes - metabolism Epidermis - metabolism Epidermis - pathology Gene Deletion Gene Knockdown Techniques Humans Immunity, Innate Inflammation - metabolism Inflammation - pathology Interleukin-18 - metabolism Keratin-1 - metabolism Keratinocytes - metabolism Keratinocytes - pathology Mice Mice, Inbred C57BL Mice, Knockout Phenotype Protein Structure, Quaternary S100 Proteins - metabolism Skin - immunology Skin - metabolism Skin - pathology Up-Regulation
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