Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged 30–90 years
Abstract The strength of trabecular bone depends on its microarchitecture and its tissue level properties. However, the interrelation between these two determinants of bone quality and their relation to age remain to be clarified. Iliac crest bone cores ( n = 152) from individuals aged 30–90 years w...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2014-09, Vol.66, p.31-38 |
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| creator | Koehne, Till Vettorazzi, Eik Küsters, Natalie Lüneburg, Rike Kahl-Nieke, Bärbel Püschel, Klaus Amling, Michael Busse, Björn |
| description | Abstract The strength of trabecular bone depends on its microarchitecture and its tissue level properties. However, the interrelation between these two determinants of bone quality and their relation to age remain to be clarified. Iliac crest bone cores ( n = 152) from individuals aged 30–90 years were analyzed by quantitative backscattered electron imaging. Univariate and multivariate analyses were conducted to determine whether epidemiological parameters (age, sex or BMI), structural histomorphometrical variables (BV/TV, Tb.Th, Tb.N and Tb.Sp) and osteoid-related indices (OV/BV, OS/BS or O.Th) predict the degree of bone mineralization. While sex and BMI were not associated with bone mineralization, age was positively correlated with the most frequently occurring calcium concentrations (Ca peak), the percentage of highly mineralized bone areas (Ca high) and, in the case of adjusted covariates, also the mean calcium content (Ca mean). Bone volume fraction and trabecular thickness were both negatively correlated with Ca mean. However, trabecular thickness was additionally associated with Ca peak, Ca high as well as the amount of low mineralized bone (Ca low) and was the only structural parameter predicting bone mineralization independent of age. Furthermore, our analyses demonstrated that osteoid variables – within a normal range (< 2% OV/BV) – were significantly associated with all mineralization parameters and represent the only predictor for the mineralization heterogeneity (Ca width). Taken together, we showed that elevated trabecular bone mineralization correlates with aging and bone loss. However, these associations are attributable to trabecular thinning that comes along with high bone mineralization due to the loss of low mineralized bone surfaces. Therefore, we demonstrated that the degree of areally resolved bone mineral is primarily associated with the amount of physiological osteoid present and the thickness of mineralized bone in trabeculae. |
| doi_str_mv | 10.1016/j.bone.2014.05.010 |
| format | Article |
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However, the interrelation between these two determinants of bone quality and their relation to age remain to be clarified. Iliac crest bone cores ( n = 152) from individuals aged 30–90 years were analyzed by quantitative backscattered electron imaging. Univariate and multivariate analyses were conducted to determine whether epidemiological parameters (age, sex or BMI), structural histomorphometrical variables (BV/TV, Tb.Th, Tb.N and Tb.Sp) and osteoid-related indices (OV/BV, OS/BS or O.Th) predict the degree of bone mineralization. While sex and BMI were not associated with bone mineralization, age was positively correlated with the most frequently occurring calcium concentrations (Ca peak), the percentage of highly mineralized bone areas (Ca high) and, in the case of adjusted covariates, also the mean calcium content (Ca mean). Bone volume fraction and trabecular thickness were both negatively correlated with Ca mean. However, trabecular thickness was additionally associated with Ca peak, Ca high as well as the amount of low mineralized bone (Ca low) and was the only structural parameter predicting bone mineralization independent of age. Furthermore, our analyses demonstrated that osteoid variables – within a normal range (< 2% OV/BV) – were significantly associated with all mineralization parameters and represent the only predictor for the mineralization heterogeneity (Ca width). Taken together, we showed that elevated trabecular bone mineralization correlates with aging and bone loss. However, these associations are attributable to trabecular thinning that comes along with high bone mineralization due to the loss of low mineralized bone surfaces. Therefore, we demonstrated that the degree of areally resolved bone mineral is primarily associated with the amount of physiological osteoid present and the thickness of mineralized bone in trabeculae.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2014.05.010</identifier><identifier>PMID: 24859568</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Bone Density - physiology ; Calcification, Physiologic - physiology ; Diseases of the osteoarticular system ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Orthopedics ; Osteoarticular system. Muscles ; Osteoporosis. Osteomalacia. Paget disease ; Pelvis - diagnostic imaging ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Tomography, X-Ray Computed ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Bone (New York, N.Y.), 2014-09, Vol.66, p.31-38</ispartof><rights>Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28725908$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24859568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koehne, Till</creatorcontrib><creatorcontrib>Vettorazzi, Eik</creatorcontrib><creatorcontrib>Küsters, Natalie</creatorcontrib><creatorcontrib>Lüneburg, Rike</creatorcontrib><creatorcontrib>Kahl-Nieke, Bärbel</creatorcontrib><creatorcontrib>Püschel, Klaus</creatorcontrib><creatorcontrib>Amling, Michael</creatorcontrib><creatorcontrib>Busse, Björn</creatorcontrib><title>Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged 30–90 years</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Abstract The strength of trabecular bone depends on its microarchitecture and its tissue level properties. However, the interrelation between these two determinants of bone quality and their relation to age remain to be clarified. Iliac crest bone cores ( n = 152) from individuals aged 30–90 years were analyzed by quantitative backscattered electron imaging. Univariate and multivariate analyses were conducted to determine whether epidemiological parameters (age, sex or BMI), structural histomorphometrical variables (BV/TV, Tb.Th, Tb.N and Tb.Sp) and osteoid-related indices (OV/BV, OS/BS or O.Th) predict the degree of bone mineralization. While sex and BMI were not associated with bone mineralization, age was positively correlated with the most frequently occurring calcium concentrations (Ca peak), the percentage of highly mineralized bone areas (Ca high) and, in the case of adjusted covariates, also the mean calcium content (Ca mean). Bone volume fraction and trabecular thickness were both negatively correlated with Ca mean. However, trabecular thickness was additionally associated with Ca peak, Ca high as well as the amount of low mineralized bone (Ca low) and was the only structural parameter predicting bone mineralization independent of age. Furthermore, our analyses demonstrated that osteoid variables – within a normal range (< 2% OV/BV) – were significantly associated with all mineralization parameters and represent the only predictor for the mineralization heterogeneity (Ca width). Taken together, we showed that elevated trabecular bone mineralization correlates with aging and bone loss. However, these associations are attributable to trabecular thinning that comes along with high bone mineralization due to the loss of low mineralized bone surfaces. Therefore, we demonstrated that the degree of areally resolved bone mineral is primarily associated with the amount of physiological osteoid present and the thickness of mineralized bone in trabeculae.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Bone Density - physiology</subject><subject>Calcification, Physiologic - physiology</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Orthopedics</subject><subject>Osteoarticular system. Muscles</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Pelvis - diagnostic imaging</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Tomography, X-Ray Computed</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkb2O1TAQhS0EYi8LL0CB3CDRJMzYcZw0SGjFn7QSBUttOfYEfEmcxU5Wuh3vwBvyJDjai6immG_O0ZnD2HOEGgHb18d6WCLVArCpQdWA8IAdsNOyErqVD9mh06qtpOjEBXuS8xEAZK_xMbsQTad61XYHNt8kij7zEPma7EBum2ziNrnvYSW3bom4jZ7vRnwOkZKduKeYw3riPuQ1hWFbwxJ3AVSiDB_ugt_slLn9Rp5L-PPrdw_8RDblp-zRWDb07Dwv2df3726uPlbXnz98unp7XZEQ7Vpp13b9KPUIgNY1vbXoqdGapLbKK-kaUAOCcu04Dgqgd2LUUqBG6KnBRl6yV_e6t2n5uVFezRyyo2mykZYtG1QKWxRayIK-OKPbMJM3tynMNp3MvxcV4OUZsNnZaUw2upD_c50Wqoede3PPUQl2FygZN4UYyskPOlE-LluKJbNBk4UB82UvZ-8Gm5JSF6O_SmqLiw</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Koehne, Till</creator><creator>Vettorazzi, Eik</creator><creator>Küsters, Natalie</creator><creator>Lüneburg, Rike</creator><creator>Kahl-Nieke, Bärbel</creator><creator>Püschel, Klaus</creator><creator>Amling, Michael</creator><creator>Busse, Björn</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged 30–90 years</title><author>Koehne, Till ; Vettorazzi, Eik ; Küsters, Natalie ; Lüneburg, Rike ; Kahl-Nieke, Bärbel ; Püschel, Klaus ; Amling, Michael ; Busse, Björn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e226t-7c689f37f001ac49aa1de477e37a5d53c405b105c6ffb5009c2f73217109e4143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Bone Density - physiology</topic><topic>Calcification, Physiologic - physiology</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Orthopedics</topic><topic>Osteoarticular system. Muscles</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Pelvis - diagnostic imaging</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Tomography, X-Ray Computed</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koehne, Till</creatorcontrib><creatorcontrib>Vettorazzi, Eik</creatorcontrib><creatorcontrib>Küsters, Natalie</creatorcontrib><creatorcontrib>Lüneburg, Rike</creatorcontrib><creatorcontrib>Kahl-Nieke, Bärbel</creatorcontrib><creatorcontrib>Püschel, Klaus</creatorcontrib><creatorcontrib>Amling, Michael</creatorcontrib><creatorcontrib>Busse, Björn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koehne, Till</au><au>Vettorazzi, Eik</au><au>Küsters, Natalie</au><au>Lüneburg, Rike</au><au>Kahl-Nieke, Bärbel</au><au>Püschel, Klaus</au><au>Amling, Michael</au><au>Busse, Björn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged 30–90 years</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>66</volume><spage>31</spage><epage>38</epage><pages>31-38</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>Abstract The strength of trabecular bone depends on its microarchitecture and its tissue level properties. However, the interrelation between these two determinants of bone quality and their relation to age remain to be clarified. Iliac crest bone cores ( n = 152) from individuals aged 30–90 years were analyzed by quantitative backscattered electron imaging. Univariate and multivariate analyses were conducted to determine whether epidemiological parameters (age, sex or BMI), structural histomorphometrical variables (BV/TV, Tb.Th, Tb.N and Tb.Sp) and osteoid-related indices (OV/BV, OS/BS or O.Th) predict the degree of bone mineralization. While sex and BMI were not associated with bone mineralization, age was positively correlated with the most frequently occurring calcium concentrations (Ca peak), the percentage of highly mineralized bone areas (Ca high) and, in the case of adjusted covariates, also the mean calcium content (Ca mean). Bone volume fraction and trabecular thickness were both negatively correlated with Ca mean. However, trabecular thickness was additionally associated with Ca peak, Ca high as well as the amount of low mineralized bone (Ca low) and was the only structural parameter predicting bone mineralization independent of age. Furthermore, our analyses demonstrated that osteoid variables – within a normal range (< 2% OV/BV) – were significantly associated with all mineralization parameters and represent the only predictor for the mineralization heterogeneity (Ca width). Taken together, we showed that elevated trabecular bone mineralization correlates with aging and bone loss. However, these associations are attributable to trabecular thinning that comes along with high bone mineralization due to the loss of low mineralized bone surfaces. Therefore, we demonstrated that the degree of areally resolved bone mineral is primarily associated with the amount of physiological osteoid present and the thickness of mineralized bone in trabeculae.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>24859568</pmid><doi>10.1016/j.bone.2014.05.010</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aging - physiology Biological and medical sciences Bone Density - physiology Calcification, Physiologic - physiology Diseases of the osteoarticular system Female Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Multivariate Analysis Orthopedics Osteoarticular system. Muscles Osteoporosis. Osteomalacia. Paget disease Pelvis - diagnostic imaging Radiodiagnosis. Nmr imagery. Nmr spectrometry Tomography, X-Ray Computed Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged 30–90 years |
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