BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells

Cadmium (Cd) is a toxic heavy metal that may cause neurological disorders. We studied the mechanism underlying Cd-mediated cell death in neuronal cells. In Cd-induced neurotoxicity, caspase-3 was only modestly activated, and accordingly, zVAD-fmk, a pan-caspase inhibitor, partially attenuated cell d...

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Veröffentlicht in:	Toxicological sciences 2014-08, Vol.140 (2), p.393-402
Hauptverfasser:	Wang, Bin, Xiao, Jia-Li, Ling, Yi-Hui, Meng, Xiao-Jing, Wu, Bing, Yang, Xin-Yi, Zou, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cadmium - toxicity Cell Death - drug effects Cell Line Extracellular Signal-Regulated MAP Kinases - metabolism Humans Hypoxia-Inducible Factor 1 - physiology Male MAP Kinase Kinase 4 - metabolism Membrane Proteins - physiology Mice Mice, Inbred BALB C Neurons - cytology Neurons - drug effects Proto-Oncogene Proteins - physiology Real-Time Polymerase Chain Reaction Up-Regulation
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