Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice

Objective: Besides their role in lipid absorption, bile acids (BAs) can act as signalling molecules. Cholic acid was shown to counteract obesity and associated metabolic disorders in high-fat-diet (cHF)-fed mice while enhancing energy expenditure through induction of mitochondrial uncoupling protein...

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Veröffentlicht in:	International Journal of Obesity 2014-08, Vol.38 (8), p.1027-1034
Hauptverfasser:	Teodoro, J S, Zouhar, P, Flachs, P, Bardova, K, Janovska, P, Gomes, A P, Duarte, F V, Varela, A T, Rolo, A P, Palmeira, C M, Kopecký, J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319/2723 692/699/2743/393 Absorption Acids Adipocytes Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - metabolism Adipose Tissue, White - metabolism Animal experimentation Animals Bile acids Biological and medical sciences Biology Blotting, Western Body fat Brown adipose tissue Carbohydrates Care and treatment Chenodeoxycholic acid Chenodeoxycholic Acid - metabolism Cholic acid Corn Diet Diet, High-Fat Dyslipidemia Energy dissipation Energy expenditure Energy Metabolism Epidemiology Food Food intake Food intolerance Glucose Glucose Intolerance - metabolism Glucose tolerance Health aspects Health Promotion and Disease Prevention High fat diet Internal Medicine Ion Channels - metabolism Lipid Metabolism Lipid peroxidation Lipids Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolic syndrome X Mice Mice, Inbred C57BL Mice, Obese Mitochondria Mitochondrial Proteins - metabolism Non-shivering Obesity Obesity - metabolism Oils & fats original-article Oxidation Oxidative Stress Phenotypes Physiological aspects Physiology Proteins Public Health Real-Time Polymerase Chain Reaction Reduction Research design Reversion Shivering Signal Transduction Thermogenesis Thyroid gland Uncoupling Protein 1
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