BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells

Bcl-2-associated transcription factor 1 (BCLAF1) is known to be involved in multiple biological processes. Although several splice variants of BCLAF1 have been identified, little is known about how BCLAF1 splicing is regulated or the contribution of alternative splicing to its developmental function...

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Veröffentlicht in:	Nature communications 2014-08, Vol.5 (1), p.4581-4581, Article 4581
Hauptverfasser:	Zhou, Xuexia, Li, Xuebing, Cheng, Yuanming, Wu, Wenwu, Xie, Zhiqin, Xi, Qiulei, Han, Jun, Wu, Guohao, Fang, Jing, Feng, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/44 38/109 38/61 38/71 38/90 631/337/1645/1792 631/67/1504/1885/1393 692/420/755 Alternative Splicing Animals Antineoplastic Agents - chemistry Carcinoma - genetics Carcinoma - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell growth Cell Line, Tumor Cell Proliferation Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colorectal cancer Exons Food safety Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Kinases Lung cancer Male Mice Mice, Inbred BALB C Mice, Knockout Mice, Nude multidisciplinary Neoplasm Transplantation Oligonucleotide Array Sequence Analysis Proteins Repressor Proteins - genetics Repressor Proteins - metabolism RNA Precursors - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Science Science (multidisciplinary) Serine-Arginine Splicing Factors Transcription factors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumorigenesis Up-Regulation
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