Plasma glucocorticoids differentially modulate phasic and tonic GABA inhibition during early postnatal development in rat spinal lamina II

•Plasma CORT regulates phasic but not tonic GABA spinal inhibition.•Hypercortisolemic rats display enhanced phasic GABA inhibition during development.•Rat with high plasma CORT level exhibited reduced mechanical pain sensitivity.•Extrasynaptic GABA current increases during the first postnatal weeks....

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Veröffentlicht in:	Neuroscience letters 2014-08, Vol.578, p.39-43
Hauptverfasser:	Zell, Vivien, Hanesch, Ulrike, Poisbeau, Pierrick, Anton, Fernand, Darbon, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals GABA extrasynaptic transmission GABA synaptic transmission Glucocorticoids Glucocorticoids - blood Inhibitory Postsynaptic Potentials Mechanical pain sensitivity Neural Inhibition Neurons - physiology Nociception - physiology Pain Threshold - physiology Rats Rats, Inbred Lew Rats, Sprague-Dawley Receptors, GABA-A - metabolism Spinal Cord Dorsal Horn - growth & development Spinal dorsal horn
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