Phenotypic drug screening and target validation for improved personalized therapy reveal the complexity of phenotype-genotype correlations in clear cell renal cell carcinoma

Abstract Objectives Novel personalized therapeutic approaches are urgently needed for patients with metastatic clear cell renal cell carcinoma (ccRCC). Methods and materials We combined the development of a primary patient-derived ccRCC cell line with a phenotypic drug screen consisting of 101 appro...

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Veröffentlicht in:	Urologic oncology 2014-08, Vol.32 (6), p.877-884
Hauptverfasser:	Schneider, Meike, Schüler, Julia, Höfflin, Rouven, Korzeniewski, Nina, Grüllich, Carsten, Roth, Wilfried, Teber, Dogu, Hadaschik, Boris, Pahernik, Sascha, Hohenfellner, Markus, Duensing, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - genetics Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Drug Screening Assays, Antitumor - methods Gene Expression Regulation, Neoplastic - drug effects Genetic Predisposition to Disease - genetics Genotype Humans Immunoblotting Kidney Neoplasms - genetics Kidney Neoplasms - pathology Molecular Targeted Therapy - methods Mutation Phenotype Precision Medicine - methods Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Pyrazoles - pharmacology Pyridines - pharmacology Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction RNA Interference Urology
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