Retinoic acid acts as a selective human IgA switch factor

Abstract Retinoic acid (RA) is known to have several functions that lead to a potent mucosal IgA response. Nevertheless, its exact role in human IgA synthesis has yet to be elucidated. Thus, we investigated the role of RA in promoting IgA isotype switching in human B cells. We found that RA increase...

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Veröffentlicht in:	Human immunology 2014-08, Vol.75 (8), p.923-929
Hauptverfasser:	Seo, Goo-Young, Jang, Young-Saeng, Kim, Jini, Choe, Jongseon, Han, Hye-Ju, Lee, Jeong-Min, Kang, Seong-Ho, Rhee, Ki-Jong, Park, Seok-Rae, Kim, Woan-Sub, Kim, Pyeung-Hyeun
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology B cell B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Benzoates - pharmacology Class switch Dibenzazepines - pharmacology Gene Expression Regulation Humans IgA Immunoglobulin A - genetics Immunoglobulin A - immunology Immunoglobulin Class Switching - drug effects Immunoglobulin G Immunoglobulin M Palatine Tonsil - cytology Palatine Tonsil - immunology Primary Cell Culture RARα Receptors, Retinoic Acid - agonists Receptors, Retinoic Acid - antagonists & inhibitors Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - immunology Retinoic acid Retinoic Acid Receptor alpha RNA, Messenger - genetics RNA, Messenger - immunology Signal Transduction Tetrahydronaphthalenes - pharmacology Transforming Growth Factor beta1 - pharmacology Tretinoin - pharmacology
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