Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II)

The adducts formed between trans-(dimethylamino)(methylamino)dichloridoplatinum(II), [t-PtCl2(dma)(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. I...

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Veröffentlicht in:	Inorganic chemistry 2014-08, Vol.53 (15), p.7806-7808
Hauptverfasser:	Messori, Luigi, Marzo, Tiziano, Michelucci, Elena, Russo Krauss, Irene, Navarro-Ranninger, Carmen, Quiroga, Adoracion G, Merlino, Antonello
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Cattle Crystallography, X-Ray Muramidase - chemistry Platinum Compounds - chemistry Proteins - chemistry Ribonuclease, Pancreatic - chemistry Spectrometry, Mass, Electrospray Ionization
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