Hyper-O-GlcNAcylation Inhibits the Induction of Heat Shock Protein 70 (Hsp 70) by Sodium Arsenite in HeLa Cells

O-Linked β-N-acetylglucosamine-modification (O-GlcNAcylation) is a reversible, post-translational, and regulatory modification of nuclear, mitochondrial, and cytoplasmic proteins that is responsive to cellular stress. However, the role of O-GlcNAcylation in the induction of heat shock proteins (Hsps...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2014/08/01, Vol.37(8), pp.1308-1314
Hauptverfasser:	Miura, Yuri, Sato, Takatoshi, Sakurai, Yoko, Sakai, Ryo, Hiraoka, Wakako, Endo, Tamao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - analogs & derivatives Acetylglucosamine - pharmacology Acylation arsenite Arsenites - toxicity DNA-Binding Proteins - metabolism Glucosamine - pharmacology heat shock protein 70 Heat Shock Transcription Factors HeLa Cells HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans N-Acetylglucosaminyltransferases - antagonists & inhibitors N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism O-linked β-N-acetylglucosamine (O-GlcNAc) Oxidative Stress - drug effects Oximes - pharmacology Phenylcarbamates - pharmacology Protein Processing, Post-Translational RNA, Messenger - metabolism RNA, Small Interfering - genetics Sodium Compounds - toxicity stress response Transcription Factors - metabolism
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