Effect of phenobarbital on cephaloridine toxicity and accumulation in rabbit and rat kidneys

Cephaloridine causes necrosis of renal proximal tubules in humans and laboratory animals. This antibiotic nephrotoxicity in rats has been shown to be reduced by mixed-function oxidase (MFO) inhibitors such as piperonyl butoxide and cobaltous chloride. The purpose of this study was to determine the e...

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Veröffentlicht in:	Toxicology and applied pharmacology 1982-06, Vol.64 (2), p.244-254
Hauptverfasser:	Kuo, Chao-Hen, Braselton, W.Emmett, Hook, Jerry B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - biosynthesis Cephaloridine - metabolism Cephaloridine - toxicity Enzyme Induction Female Glutathione Transferase - biosynthesis In Vitro Techniques Kidney - drug effects Kidney - metabolism Male p-Aminohippuric Acid - metabolism Phenobarbital - pharmacology Rabbits Rats Rats, Inbred F344 Species Specificity
Online-Zugang:	Volltext
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