Enhanced blood-brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation

The blood-brain barrier (BBB) is considered as the primary impediment barrier for most drugs. Delivering therapeutic agents to the brain is still a big challenge to date. In our study, a dual mechanism, receptor mediation combined with external non-invasive magnetic force, was incorporated into ferr...

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Veröffentlicht in:	Nanotechnology 2014-02, Vol.25 (5), p.055101-14
Hauptverfasser:	Ding, Hong, Sagar, Vidya, Agudelo, Marisela, Pilakka-Kanthikeel, Sudheesh, Atluri, Venkata Subba Rao, Raymond, Andrea, Samikkannu, Thangavel, Nair, Madhavan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Biological Transport, Active Biotechnology blood-brain barrier (BBB) Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain Cell Survival - drug effects Cells, Cultured Condensed matter: electronic structure, electrical, magnetic, and optical properties Drug Delivery Systems Encapsulation Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Exact sciences and technology Fluid dynamics fluorescence Fluorescent Dyes Fundamental and applied biological sciences. Psychology Humans Integrity Liposomes Liposomes - administration & dosage Magnetic fields magnetic nanoparticles (MNPs) Magnetic properties and materials Magnetics Magnetite Nanoparticles - administration & dosage Magnetite Nanoparticles - toxicity Magnetite Nanoparticles - ultrastructure magneto-liposome (ML) Methods. Procedures. Technologies Models, Biological Nanostructure Nanotechnology Optical properties and condensed-matter spectroscopy and other interactions of matter with particles and radiation Optical properties of low-dimensional, mesoscopic, and nanoscale materials and structures Others Particle Size Physics Receptors, Transferrin - metabolism Small particles and nanoscale materials Studies of specific magnetic materials Transferrin Transferrin - administration & dosage transmigration Various methods and equipments
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