Simultaneous determination of metoprolol and its metabolites, [alpha]-hydroxymetoprolol and O-desmethylmetoprolol, in human plasma by liquid chromatography with tandem mass spectrometry: Application to the pharmacokinetics of metoprolol associated with CYP2D6 genotypes

A rapid and simple LC with MS/MS method for the simultaneous determination of metoprolol and its two CYP2D6-derived metabolites, [alpha]-hydroxy- and O-desmethylmetoprolol, in human plasma was established. Metoprolol (MET), its two metabolites, and the internal standard chlorpropamide were extracted...

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Veröffentlicht in:	Journal of separation science 2014-06, Vol.37 (11), p.1256-1264
Hauptverfasser:	Bae, Soo Hyeon, Lee, Joeng Kee, Cho, Doo-Yeoun, Bae, Soo Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography Distilled water Flow rate Human Ions Liquid chromatography Mass spectrometry Metabolites Methyl alcohol Plasma Run time (computers) Separation
Online-Zugang:	Volltext
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