C5L2 is required for C5a-triggered receptor internalization and ERK signaling

C5L2 is a receptor that binds to C5a and belongs to the family of G protein-coupled receptors, but its role in physiological C5a-mediated responses remains under debate. Here we show that, like the canonical C5a receptor C5aR, C5L2 plays a pro-inflammatory role in a murine model of acute experimenta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular signalling 2014-07, Vol.26 (7), p.1409-1419
Hauptverfasser:	Hsu, Wei-Chan, Yang, Fu-Chen, Lin, Chi-Hung, Hsieh, Shie-Liang, Chen, Nien-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adaptin 2 Animals Arrestins - metabolism beta-Arrestins C5aR C5L2 Cell Membrane - metabolism Cells, Cultured Cellular Colitis, Ulcerative - immunology Complement C5a - immunology Complement C5a - metabolism Dextran Sulfate Disease Models, Animal Dynamins - antagonists & inhibitors Endocytosis - immunology Endocytosis-dependent signaling Extracellular Signal-Regulated MAP Kinases - metabolism HEK293 Cells Humans Hydrazones - pharmacology Inflammation - immunology Inflammatory bowel disease Inhibitors Macrophages, Peritoneal - immunology Male Mice Mice, Inbred BALB C Mice, Knockout Neutrophils - immunology Optimization Phosphatidylinositol 3-Kinase - metabolism Proteins Receptor, Anaphylatoxin C5a - genetics Receptor, Anaphylatoxin C5a - immunology Receptor, Anaphylatoxin C5a - metabolism Receptors Receptors, Chemokine - biosynthesis Receptors, Chemokine - genetics Receptors, Chemokine - immunology Recruitment Signal Transduction Stimulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!