Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles
[Display omitted] •Adsorption and desorption of erlotinib were examined on gold nanoparticle surfaces.•Density functional theory calculations predicted plausible binding geometries.•Surface-enhanced Raman scattering was used to investigate the interfacial structures. We investigated interfacial beha...
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| Veröffentlicht in: | Journal of colloid and interface science 2014-07, Vol.425 (425), p.96-101 |
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| creator | Lam, Anh Thu Ngoc Yoon, Jinha Ganbold, Erdene-Ochir Singh, Dheeraj K. Kim, Doseok Cho, Kwang-Hwi Son, Sang Jun Choo, Jaebum Lee, So Yeong Kim, Sehun Joo, Sang-Woo |
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•Adsorption and desorption of erlotinib were examined on gold nanoparticle surfaces.•Density functional theory calculations predicted plausible binding geometries.•Surface-enhanced Raman scattering was used to investigate the interfacial structures.
We investigated interfacial behaviors of erlotinib (EL) on gold nanoparticles (AuNPs) by means of Raman spectroscopy. The adsorption reactions and structures of EL on AuNP surfaces were examined by UV–Vis absorption spectroscopy and surface-enhanced Raman scattering (SERS). Density functional theory calculations were performed to estimate the energetic stabilities of the drug-AuNP composites. Among the binding units in EL, the acetylenic CC group was calculated to be the most strongly binding on the AuNP cluster atoms, consistent with the SERS spectra. The concentration-dependent SERS spectra indicated that ∼10−5M of EL exhibited the highest SERS signals. The attached EL appeared to desorb more efficiently with 2mM glutathione than with cell culture media. The lack of a strong SERS signal of EL in the dark-field microscopy images of AuNP-EL complexes suggested almost complete desorption of EL inside cells. |
| doi_str_mv | 10.1016/j.jcis.2014.03.032 |
| format | Article |
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•Adsorption and desorption of erlotinib were examined on gold nanoparticle surfaces.•Density functional theory calculations predicted plausible binding geometries.•Surface-enhanced Raman scattering was used to investigate the interfacial structures.
We investigated interfacial behaviors of erlotinib (EL) on gold nanoparticles (AuNPs) by means of Raman spectroscopy. The adsorption reactions and structures of EL on AuNP surfaces were examined by UV–Vis absorption spectroscopy and surface-enhanced Raman scattering (SERS). Density functional theory calculations were performed to estimate the energetic stabilities of the drug-AuNP composites. Among the binding units in EL, the acetylenic CC group was calculated to be the most strongly binding on the AuNP cluster atoms, consistent with the SERS spectra. The concentration-dependent SERS spectra indicated that ∼10−5M of EL exhibited the highest SERS signals. The attached EL appeared to desorb more efficiently with 2mM glutathione than with cell culture media. The lack of a strong SERS signal of EL in the dark-field microscopy images of AuNP-EL complexes suggested almost complete desorption of EL inside cells.</description><identifier>ISSN: 0021-9797</identifier><identifier>EISSN: 1095-7103</identifier><identifier>DOI: 10.1016/j.jcis.2014.03.032</identifier><identifier>PMID: 24776669</identifier><identifier>CODEN: JCISA5</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adsorption ; Binding ; Chemistry ; Colloidal state and disperse state ; Density functional theory ; Desorption ; Erlotinib ; Erlotinib Hydrochloride ; Exact sciences and technology ; General and physical chemistry ; Gold - chemistry ; Gold nanoparticles ; Inhibitors ; Interfacial structures ; Kinases ; Mathematical analysis ; Metal Nanoparticles ; Physical and chemical studies. Granulometry. Electrokinetic phenomena ; Protein Kinase Inhibitors - chemistry ; Protein-Tyrosine Kinases - antagonists & inhibitors ; Quinazolines - chemistry ; Raman scattering ; Raman spectroscopy ; Spectra ; Spectrum Analysis, Raman ; Surface chemistry ; Surface physical chemistry</subject><ispartof>Journal of colloid and interface science, 2014-07, Vol.425 (425), p.96-101</ispartof><rights>2014 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-cf62a97cc40b06c91efc1975b2cd04f12fe20b1eaad087ec8f7a33c0a297a1c13</citedby><cites>FETCH-LOGICAL-c485t-cf62a97cc40b06c91efc1975b2cd04f12fe20b1eaad087ec8f7a33c0a297a1c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcis.2014.03.032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28465677$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24776669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lam, Anh Thu Ngoc</creatorcontrib><creatorcontrib>Yoon, Jinha</creatorcontrib><creatorcontrib>Ganbold, Erdene-Ochir</creatorcontrib><creatorcontrib>Singh, Dheeraj K.</creatorcontrib><creatorcontrib>Kim, Doseok</creatorcontrib><creatorcontrib>Cho, Kwang-Hwi</creatorcontrib><creatorcontrib>Son, Sang Jun</creatorcontrib><creatorcontrib>Choo, Jaebum</creatorcontrib><creatorcontrib>Lee, So Yeong</creatorcontrib><creatorcontrib>Kim, Sehun</creatorcontrib><creatorcontrib>Joo, Sang-Woo</creatorcontrib><title>Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles</title><title>Journal of colloid and interface science</title><addtitle>J Colloid Interface Sci</addtitle><description>[Display omitted]
•Adsorption and desorption of erlotinib were examined on gold nanoparticle surfaces.•Density functional theory calculations predicted plausible binding geometries.•Surface-enhanced Raman scattering was used to investigate the interfacial structures.
We investigated interfacial behaviors of erlotinib (EL) on gold nanoparticles (AuNPs) by means of Raman spectroscopy. The adsorption reactions and structures of EL on AuNP surfaces were examined by UV–Vis absorption spectroscopy and surface-enhanced Raman scattering (SERS). Density functional theory calculations were performed to estimate the energetic stabilities of the drug-AuNP composites. Among the binding units in EL, the acetylenic CC group was calculated to be the most strongly binding on the AuNP cluster atoms, consistent with the SERS spectra. The concentration-dependent SERS spectra indicated that ∼10−5M of EL exhibited the highest SERS signals. The attached EL appeared to desorb more efficiently with 2mM glutathione than with cell culture media. The lack of a strong SERS signal of EL in the dark-field microscopy images of AuNP-EL complexes suggested almost complete desorption of EL inside cells.</description><subject>Adsorption</subject><subject>Binding</subject><subject>Chemistry</subject><subject>Colloidal state and disperse state</subject><subject>Density functional theory</subject><subject>Desorption</subject><subject>Erlotinib</subject><subject>Erlotinib Hydrochloride</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Gold - chemistry</subject><subject>Gold nanoparticles</subject><subject>Inhibitors</subject><subject>Interfacial structures</subject><subject>Kinases</subject><subject>Mathematical analysis</subject><subject>Metal Nanoparticles</subject><subject>Physical and chemical studies. Granulometry. Electrokinetic phenomena</subject><subject>Protein Kinase Inhibitors - chemistry</subject><subject>Protein-Tyrosine Kinases - antagonists & inhibitors</subject><subject>Quinazolines - chemistry</subject><subject>Raman scattering</subject><subject>Raman spectroscopy</subject><subject>Spectra</subject><subject>Spectrum Analysis, Raman</subject><subject>Surface chemistry</subject><subject>Surface physical chemistry</subject><issn>0021-9797</issn><issn>1095-7103</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2LFDEQhoMo7rj6BzxIX4S99GxV-iMT8LIs6wcs7EW9hnSlWjP2JGPSs7D_3jQzzlGEgqLgqZeqR4i3CGsE7K-36y35vJaA7RqaUvKZWCHorlYIzXOxApBYa6XVhXiV8xYAsev0S3EhW6X6vtcr8f3G5Zj2s4-hssFVjs9jHKv5KcXsA1e_fLCZKx9--sHPMVWcpjj74IeqkD_i5KpgQ9zbNHuaOL8WL0Y7ZX5z6pfi28e7r7ef6_uHT19ub-5rajfdXNPYS6sVUQsD9KSRR0KtukGSg3ZEObKEAdlaBxvFtBmVbRoCK7WySNhciqtj7j7F3wfOs9n5TDxNNnA8ZFP-RWgb3cn_QItIBKWgoPKIUnk_Jx7NPvmdTU8GwSzqzdYs6s2i3kBTasl_d8o_DDt255W_rgvw_gTYTHYakw1LxpnbtH3XK1W4D0eOi7hHz8lk8hyInU9Ms3HR_-uOPxFAozA</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Lam, Anh Thu Ngoc</creator><creator>Yoon, Jinha</creator><creator>Ganbold, Erdene-Ochir</creator><creator>Singh, Dheeraj K.</creator><creator>Kim, Doseok</creator><creator>Cho, Kwang-Hwi</creator><creator>Son, Sang Jun</creator><creator>Choo, Jaebum</creator><creator>Lee, So Yeong</creator><creator>Kim, Sehun</creator><creator>Joo, Sang-Woo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20140701</creationdate><title>Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles</title><author>Lam, Anh Thu Ngoc ; Yoon, Jinha ; Ganbold, Erdene-Ochir ; Singh, Dheeraj K. ; Kim, Doseok ; Cho, Kwang-Hwi ; Son, Sang Jun ; Choo, Jaebum ; Lee, So Yeong ; Kim, Sehun ; Joo, Sang-Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-cf62a97cc40b06c91efc1975b2cd04f12fe20b1eaad087ec8f7a33c0a297a1c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adsorption</topic><topic>Binding</topic><topic>Chemistry</topic><topic>Colloidal state and disperse state</topic><topic>Density functional theory</topic><topic>Desorption</topic><topic>Erlotinib</topic><topic>Erlotinib Hydrochloride</topic><topic>Exact sciences and technology</topic><topic>General and physical chemistry</topic><topic>Gold - chemistry</topic><topic>Gold nanoparticles</topic><topic>Inhibitors</topic><topic>Interfacial structures</topic><topic>Kinases</topic><topic>Mathematical analysis</topic><topic>Metal Nanoparticles</topic><topic>Physical and chemical studies. Granulometry. Electrokinetic phenomena</topic><topic>Protein Kinase Inhibitors - chemistry</topic><topic>Protein-Tyrosine Kinases - antagonists & inhibitors</topic><topic>Quinazolines - chemistry</topic><topic>Raman scattering</topic><topic>Raman spectroscopy</topic><topic>Spectra</topic><topic>Spectrum Analysis, Raman</topic><topic>Surface chemistry</topic><topic>Surface physical chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lam, Anh Thu Ngoc</creatorcontrib><creatorcontrib>Yoon, Jinha</creatorcontrib><creatorcontrib>Ganbold, Erdene-Ochir</creatorcontrib><creatorcontrib>Singh, Dheeraj K.</creatorcontrib><creatorcontrib>Kim, Doseok</creatorcontrib><creatorcontrib>Cho, Kwang-Hwi</creatorcontrib><creatorcontrib>Son, Sang Jun</creatorcontrib><creatorcontrib>Choo, Jaebum</creatorcontrib><creatorcontrib>Lee, So Yeong</creatorcontrib><creatorcontrib>Kim, Sehun</creatorcontrib><creatorcontrib>Joo, Sang-Woo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of colloid and interface science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lam, Anh Thu Ngoc</au><au>Yoon, Jinha</au><au>Ganbold, Erdene-Ochir</au><au>Singh, Dheeraj K.</au><au>Kim, Doseok</au><au>Cho, Kwang-Hwi</au><au>Son, Sang Jun</au><au>Choo, Jaebum</au><au>Lee, So Yeong</au><au>Kim, Sehun</au><au>Joo, Sang-Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles</atitle><jtitle>Journal of colloid and interface science</jtitle><addtitle>J Colloid Interface Sci</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>425</volume><issue>425</issue><spage>96</spage><epage>101</epage><pages>96-101</pages><issn>0021-9797</issn><eissn>1095-7103</eissn><coden>JCISA5</coden><abstract>[Display omitted]
•Adsorption and desorption of erlotinib were examined on gold nanoparticle surfaces.•Density functional theory calculations predicted plausible binding geometries.•Surface-enhanced Raman scattering was used to investigate the interfacial structures.
We investigated interfacial behaviors of erlotinib (EL) on gold nanoparticles (AuNPs) by means of Raman spectroscopy. The adsorption reactions and structures of EL on AuNP surfaces were examined by UV–Vis absorption spectroscopy and surface-enhanced Raman scattering (SERS). Density functional theory calculations were performed to estimate the energetic stabilities of the drug-AuNP composites. Among the binding units in EL, the acetylenic CC group was calculated to be the most strongly binding on the AuNP cluster atoms, consistent with the SERS spectra. The concentration-dependent SERS spectra indicated that ∼10−5M of EL exhibited the highest SERS signals. The attached EL appeared to desorb more efficiently with 2mM glutathione than with cell culture media. The lack of a strong SERS signal of EL in the dark-field microscopy images of AuNP-EL complexes suggested almost complete desorption of EL inside cells.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>24776669</pmid><doi>10.1016/j.jcis.2014.03.032</doi><tpages>6</tpages></addata></record> |
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| subjects | Adsorption Binding Chemistry Colloidal state and disperse state Density functional theory Desorption Erlotinib Erlotinib Hydrochloride Exact sciences and technology General and physical chemistry Gold - chemistry Gold nanoparticles Inhibitors Interfacial structures Kinases Mathematical analysis Metal Nanoparticles Physical and chemical studies. Granulometry. Electrokinetic phenomena Protein Kinase Inhibitors - chemistry Protein-Tyrosine Kinases - antagonists & inhibitors Quinazolines - chemistry Raman scattering Raman spectroscopy Spectra Spectrum Analysis, Raman Surface chemistry Surface physical chemistry |
| title | Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles |
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