A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation

Aims/hypothesis Modification of the structure of glucagon could provide useful compounds for the potential treatment of obesity-related diabetes. Methods This study evaluated N -acetyl-glucagon, ( d -Ser 2 )glucagon and an analogue of ( d -Ser 2 )glucagon with the addition of nine amino acids from t...

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Veröffentlicht in:	Diabetologia 2014-09, Vol.57 (9), p.1927-1936
Hauptverfasser:	Lynch, Aisling M., Pathak, Nupur, Pathak, Varun, O’Harte, Finbarr P. M., Flatt, Peter R., Irwin, Nigel, Gault, Victor A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biological and medical sciences Blood Glucose - metabolism Body Weight Diabetes Diabetes Mellitus - drug therapy Diabetes Mellitus - etiology Diabetes Mellitus - metabolism Diabetes. Impaired glucose tolerance Dipeptidyl Peptidase 4 - therapeutic use Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucagon Glucagon - analogs & derivatives Glucagon - metabolism Glucagon - therapeutic use Glucagon-Like Peptide-1 Receptor Glucose Homeostasis Human Physiology Hypoglycemic Agents - therapeutic use Insulin Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Knockout Obesity Obesity - complications Obesity - metabolism Polypeptides Receptors, Glucagon - metabolism Weight control
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