Effects of Antenatal Hypoxia on the Parameters of Tissue Homeostasis in the Liver of Albino Rats
We studied age-dependent dynamics of some liver parameters in albino rats after antenatal hypoxia. A decrease in body weight, absolute liver weight in newborn and mature rats, and a reduction of relative weight of the liver in mature animals were observed under these conditions. It was found that an...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2014-07, Vol.157 (3), p.327-329 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Pinaeva, O. G. Lebed’ko, O. A. Yakovenko, D. V. Timoshin, S. S. Pinaev, S. K. Sazonova, E. N. |
| description | We studied age-dependent dynamics of some liver parameters in albino rats after antenatal hypoxia. A decrease in body weight, absolute liver weight in newborn and mature rats, and a reduction of relative weight of the liver in mature animals were observed under these conditions. It was found that antenatal hypoxia promotes a decrease in DNA-synthetic activity of hepatocytes, intensifies free radical processes in the liver of newborn rats, and reduces the number of nucleoli in hepatocytes. In mature animals, antenatal hypoxia was followed by a decrease in hepatocyte sizes and area of nucleoli, an increase in the number of binuclear cells relative to mononuclear cells, and a decrease in the number of nucleoli in hepatocyte nuclei. These data can reflect impairment of tissue homeostasis in the liver of mammals exposed to antenatal hypoxia. |
| doi_str_mv | 10.1007/s10517-014-2557-2 |
| format | Article |
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| subjects | Animals Animals, Outbred Strains Biomedical and Life Sciences Biomedicine Body Weight Cell Biology Cell Hypoxia DNA Female Hepatocytes - physiology Homeostasis Internal Medicine Laboratory Medicine Liver - pathology Organ Size Pathology Pregnancy Prenatal Exposure Delayed Effects - pathology Rats S Phase Cell Cycle Checkpoints |
| title | Effects of Antenatal Hypoxia on the Parameters of Tissue Homeostasis in the Liver of Albino Rats |
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