Comparing Efficacy of Three Methods of Tranexamic Acid Administration in Reducing Hemoglobin Drop Following Total Knee Arthroplasty
Abstract The ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four groups. In group 1, 500 mg TXA was administered intravenously. In group 2, the joint irrigated with 3 g o...
Gespeichert in:
| Veröffentlicht in: | The Journal of arthroplasty 2014-08, Vol.29 (8), p.1521-1524 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1524 |
|---|---|
| container_issue | 8 |
| container_start_page | 1521 |
| container_title | The Journal of arthroplasty |
| container_volume | 29 |
| creator | Sarzaeem, Mohammad Mahdi, MD Razi, Mohammad, MD Kazemian, Gholamhosein, MD Moghaddam, Mohammad Emami, MD Rasi, Alireza Manafi, MD Karimi, Meysam, MBE |
| description | Abstract The ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four groups. In group 1, 500 mg TXA was administered intravenously. In group 2, the joint irrigated with 3 g of TXA in 100 cc of saline. In group 3, 1.5 g of TXA was injected through the drain. Group 4 did not take TXA. Albeit all methods had a statistical effect on hemoglobin drop, drainage and number of transfused units when compared to controls, but intravenous injection of TXA seems to be much more effective in terms of reducing hemoglobin drop and transfused units; and what's more TXA injection by drain is more effective regarding to reducing postoperative drainage. |
| doi_str_mv | 10.1016/j.arth.2014.02.031 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1551025534</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0883540314001454</els_id><sourcerecordid>1551025534</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-fd0a41974c47bbfa972b265a2ceee72d0668bd0650c8f8f56f2bcfcf1d9dce7a3</originalsourceid><addsrcrecordid>eNp9kUFv1DAUhC1ERbeFP8AB-cglwXbsJCshpNXS0qpFSLCcLcd-7npx4sVOoHvuH8dhCwcOXGzJb2bk9w1CLykpKaH1m12p4rgtGaG8JKwkFX2CFlRUrGg5qZ-iBWnbqhCcVKfoLKUdIZQKwZ-hU8YbVtOGL9DDOvR7Fd1why-sdVrpAw4Wb7YRAH-EcRtM-v0Q1QD3qncar7QzeGV6N7g0RjW6MGA34M9gJj3nXEEf7nzo8tv7GPb4Mngffs6TTRiVxzdDjl7ln-ehV2k8PEcnVvkELx7vc_T18mKzvipuP324Xq9uC81bOhbWEMXpsuGaN11n1bJhHauFYhoAGmZIXbddPgXRrW2tqC3rtNWWmqXR0KjqHL0-5u5j-D5BGmXvkgbv82phSjLDoYQJUfEsZUepjiGlCFbuo-tVPEhK5Axf7uQMX87wJWEyw8-mV4_5U9eD-Wv5QzsL3h4FkLf84SDKpB0MGoyLoEdpgvt__rt_7NrnErTy3-AAaRemOGR-ksqUDfLLXP_cPuW5eS549Qs6CK0n</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1551025534</pqid></control><display><type>article</type><title>Comparing Efficacy of Three Methods of Tranexamic Acid Administration in Reducing Hemoglobin Drop Following Total Knee Arthroplasty</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Sarzaeem, Mohammad Mahdi, MD ; Razi, Mohammad, MD ; Kazemian, Gholamhosein, MD ; Moghaddam, Mohammad Emami, MD ; Rasi, Alireza Manafi, MD ; Karimi, Meysam, MBE</creator><creatorcontrib>Sarzaeem, Mohammad Mahdi, MD ; Razi, Mohammad, MD ; Kazemian, Gholamhosein, MD ; Moghaddam, Mohammad Emami, MD ; Rasi, Alireza Manafi, MD ; Karimi, Meysam, MBE</creatorcontrib><description>Abstract The ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four groups. In group 1, 500 mg TXA was administered intravenously. In group 2, the joint irrigated with 3 g of TXA in 100 cc of saline. In group 3, 1.5 g of TXA was injected through the drain. Group 4 did not take TXA. Albeit all methods had a statistical effect on hemoglobin drop, drainage and number of transfused units when compared to controls, but intravenous injection of TXA seems to be much more effective in terms of reducing hemoglobin drop and transfused units; and what's more TXA injection by drain is more effective regarding to reducing postoperative drainage.</description><identifier>ISSN: 0883-5403</identifier><identifier>EISSN: 1532-8406</identifier><identifier>DOI: 10.1016/j.arth.2014.02.031</identifier><identifier>PMID: 24726174</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Antifibrinolytic Agents - administration & dosage ; Arthroplasty, Replacement, Knee - adverse effects ; Blood Loss, Surgical - prevention & control ; Blood Transfusion ; Drainage - methods ; Female ; hemoglobin drop ; Hemoglobins - metabolism ; Humans ; Injections, Intra-Articular ; Injections, Intravenous ; intra-articular injection ; intravenous injection ; Male ; Middle Aged ; Orthopedics ; Sodium Chloride - administration & dosage ; total knee arthroplasty ; tranexamic acid ; Tranexamic Acid - administration & dosage ; Treatment Outcome</subject><ispartof>The Journal of arthroplasty, 2014-08, Vol.29 (8), p.1521-1524</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-fd0a41974c47bbfa972b265a2ceee72d0668bd0650c8f8f56f2bcfcf1d9dce7a3</citedby><cites>FETCH-LOGICAL-c481t-fd0a41974c47bbfa972b265a2ceee72d0668bd0650c8f8f56f2bcfcf1d9dce7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0883540314001454$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24726174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarzaeem, Mohammad Mahdi, MD</creatorcontrib><creatorcontrib>Razi, Mohammad, MD</creatorcontrib><creatorcontrib>Kazemian, Gholamhosein, MD</creatorcontrib><creatorcontrib>Moghaddam, Mohammad Emami, MD</creatorcontrib><creatorcontrib>Rasi, Alireza Manafi, MD</creatorcontrib><creatorcontrib>Karimi, Meysam, MBE</creatorcontrib><title>Comparing Efficacy of Three Methods of Tranexamic Acid Administration in Reducing Hemoglobin Drop Following Total Knee Arthroplasty</title><title>The Journal of arthroplasty</title><addtitle>J Arthroplasty</addtitle><description>Abstract The ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four groups. In group 1, 500 mg TXA was administered intravenously. In group 2, the joint irrigated with 3 g of TXA in 100 cc of saline. In group 3, 1.5 g of TXA was injected through the drain. Group 4 did not take TXA. Albeit all methods had a statistical effect on hemoglobin drop, drainage and number of transfused units when compared to controls, but intravenous injection of TXA seems to be much more effective in terms of reducing hemoglobin drop and transfused units; and what's more TXA injection by drain is more effective regarding to reducing postoperative drainage.</description><subject>Aged</subject><subject>Antifibrinolytic Agents - administration & dosage</subject><subject>Arthroplasty, Replacement, Knee - adverse effects</subject><subject>Blood Loss, Surgical - prevention & control</subject><subject>Blood Transfusion</subject><subject>Drainage - methods</subject><subject>Female</subject><subject>hemoglobin drop</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Injections, Intra-Articular</subject><subject>Injections, Intravenous</subject><subject>intra-articular injection</subject><subject>intravenous injection</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Sodium Chloride - administration & dosage</subject><subject>total knee arthroplasty</subject><subject>tranexamic acid</subject><subject>Tranexamic Acid - administration & dosage</subject><subject>Treatment Outcome</subject><issn>0883-5403</issn><issn>1532-8406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAUhC1ERbeFP8AB-cglwXbsJCshpNXS0qpFSLCcLcd-7npx4sVOoHvuH8dhCwcOXGzJb2bk9w1CLykpKaH1m12p4rgtGaG8JKwkFX2CFlRUrGg5qZ-iBWnbqhCcVKfoLKUdIZQKwZ-hU8YbVtOGL9DDOvR7Fd1why-sdVrpAw4Wb7YRAH-EcRtM-v0Q1QD3qncar7QzeGV6N7g0RjW6MGA34M9gJj3nXEEf7nzo8tv7GPb4Mngffs6TTRiVxzdDjl7ln-ehV2k8PEcnVvkELx7vc_T18mKzvipuP324Xq9uC81bOhbWEMXpsuGaN11n1bJhHauFYhoAGmZIXbddPgXRrW2tqC3rtNWWmqXR0KjqHL0-5u5j-D5BGmXvkgbv82phSjLDoYQJUfEsZUepjiGlCFbuo-tVPEhK5Axf7uQMX87wJWEyw8-mV4_5U9eD-Wv5QzsL3h4FkLf84SDKpB0MGoyLoEdpgvt__rt_7NrnErTy3-AAaRemOGR-ksqUDfLLXP_cPuW5eS549Qs6CK0n</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Sarzaeem, Mohammad Mahdi, MD</creator><creator>Razi, Mohammad, MD</creator><creator>Kazemian, Gholamhosein, MD</creator><creator>Moghaddam, Mohammad Emami, MD</creator><creator>Rasi, Alireza Manafi, MD</creator><creator>Karimi, Meysam, MBE</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Comparing Efficacy of Three Methods of Tranexamic Acid Administration in Reducing Hemoglobin Drop Following Total Knee Arthroplasty</title><author>Sarzaeem, Mohammad Mahdi, MD ; Razi, Mohammad, MD ; Kazemian, Gholamhosein, MD ; Moghaddam, Mohammad Emami, MD ; Rasi, Alireza Manafi, MD ; Karimi, Meysam, MBE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-fd0a41974c47bbfa972b265a2ceee72d0668bd0650c8f8f56f2bcfcf1d9dce7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Antifibrinolytic Agents - administration & dosage</topic><topic>Arthroplasty, Replacement, Knee - adverse effects</topic><topic>Blood Loss, Surgical - prevention & control</topic><topic>Blood Transfusion</topic><topic>Drainage - methods</topic><topic>Female</topic><topic>hemoglobin drop</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Injections, Intra-Articular</topic><topic>Injections, Intravenous</topic><topic>intra-articular injection</topic><topic>intravenous injection</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Sodium Chloride - administration & dosage</topic><topic>total knee arthroplasty</topic><topic>tranexamic acid</topic><topic>Tranexamic Acid - administration & dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarzaeem, Mohammad Mahdi, MD</creatorcontrib><creatorcontrib>Razi, Mohammad, MD</creatorcontrib><creatorcontrib>Kazemian, Gholamhosein, MD</creatorcontrib><creatorcontrib>Moghaddam, Mohammad Emami, MD</creatorcontrib><creatorcontrib>Rasi, Alireza Manafi, MD</creatorcontrib><creatorcontrib>Karimi, Meysam, MBE</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of arthroplasty</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarzaeem, Mohammad Mahdi, MD</au><au>Razi, Mohammad, MD</au><au>Kazemian, Gholamhosein, MD</au><au>Moghaddam, Mohammad Emami, MD</au><au>Rasi, Alireza Manafi, MD</au><au>Karimi, Meysam, MBE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparing Efficacy of Three Methods of Tranexamic Acid Administration in Reducing Hemoglobin Drop Following Total Knee Arthroplasty</atitle><jtitle>The Journal of arthroplasty</jtitle><addtitle>J Arthroplasty</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>29</volume><issue>8</issue><spage>1521</spage><epage>1524</epage><pages>1521-1524</pages><issn>0883-5403</issn><eissn>1532-8406</eissn><abstract>Abstract The ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four groups. In group 1, 500 mg TXA was administered intravenously. In group 2, the joint irrigated with 3 g of TXA in 100 cc of saline. In group 3, 1.5 g of TXA was injected through the drain. Group 4 did not take TXA. Albeit all methods had a statistical effect on hemoglobin drop, drainage and number of transfused units when compared to controls, but intravenous injection of TXA seems to be much more effective in terms of reducing hemoglobin drop and transfused units; and what's more TXA injection by drain is more effective regarding to reducing postoperative drainage.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24726174</pmid><doi>10.1016/j.arth.2014.02.031</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0883-5403 |
| ispartof | The Journal of arthroplasty, 2014-08, Vol.29 (8), p.1521-1524 |
| issn | 0883-5403 1532-8406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1551025534 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Antifibrinolytic Agents - administration & dosage Arthroplasty, Replacement, Knee - adverse effects Blood Loss, Surgical - prevention & control Blood Transfusion Drainage - methods Female hemoglobin drop Hemoglobins - metabolism Humans Injections, Intra-Articular Injections, Intravenous intra-articular injection intravenous injection Male Middle Aged Orthopedics Sodium Chloride - administration & dosage total knee arthroplasty tranexamic acid Tranexamic Acid - administration & dosage Treatment Outcome |
| title | Comparing Efficacy of Three Methods of Tranexamic Acid Administration in Reducing Hemoglobin Drop Following Total Knee Arthroplasty |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T09%3A54%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparing%20Efficacy%20of%20Three%20Methods%20of%20Tranexamic%20Acid%20Administration%20in%20Reducing%20Hemoglobin%20Drop%20Following%20Total%20Knee%20Arthroplasty&rft.jtitle=The%20Journal%20of%20arthroplasty&rft.au=Sarzaeem,%20Mohammad%20Mahdi,%20MD&rft.date=2014-08-01&rft.volume=29&rft.issue=8&rft.spage=1521&rft.epage=1524&rft.pages=1521-1524&rft.issn=0883-5403&rft.eissn=1532-8406&rft_id=info:doi/10.1016/j.arth.2014.02.031&rft_dat=%3Cproquest_cross%3E1551025534%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1551025534&rft_id=info:pmid/24726174&rft_els_id=1_s2_0_S0883540314001454&rfr_iscdi=true |