Phosphatidylinositol-4,5-bisphosphate ionization in the presence of cholesterol, calcium or magnesium ions

•Ca2+ has a much larger effect on the ionization state of PI(4,5)P2 than Mg2+ at the same concentration.•Cholesterol effects the ionization of PI(4,5)P2 via a direct interaction with the headgroup of PI(4,5)P2.•Interactions of cholesterol, Ca2+ and Mg2+ affect the ionization of the 5-phosphate more...

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Veröffentlicht in:	Chemistry and physics of lipids 2014-09, Vol.182, p.62-72
Hauptverfasser:	Graber, Zachary T., Gericke, Arne, Kooijman, Edgar E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Calcium - pharmacology Cholesterol - metabolism Cholesterol - pharmacology Lipid domain formation Lipid electrostatics Lipid signaling Magnesium - metabolism Magnesium - pharmacology Model membranes Phosphatidylinositol 4,5-Diphosphate - chemistry Phosphatidylinositol 4,5-Diphosphate - metabolism PI(4,5)P2 Solid-state 31P NMR
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