Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients
Measuring the levels of the plasma free metanephrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe. As this test has not yet been evaluated in Japan, it is necessary to evaluate the diagnostic efficacy of measuring th...
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| Veröffentlicht in: | ENDOCRINE JOURNAL 2014, Vol.61(7), pp.667-673 |
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| creator | Tanaka, Yuko Isobe, Kazumasa Ma, Enbo Imai, Tsuneo Kikumori, Toyone Matsuda, Tadashi Maeda, Yuji Sakurai, Akihiro Midorikawa, Sanae Hataya, Yuji Kato, Taiya Kamide, Kei Ikeda, Yukihiro Okada, Yosuke Adachi, Masahiro Yanase, Toshihiko Takahashi, Hideto Yokoyama, Chie Arai, Yusuke Hashimoto, Koichi Shimano, Hitoshi Hara, Hisato Kawakami, Yasushi Takekoshi, Kazuhiro |
| description | Measuring the levels of the plasma free metanephrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe. As this test has not yet been evaluated in Japan, it is necessary to evaluate the diagnostic efficacy of measuring the levels of PFMs compared with the standard measurement of the urinary excretion of metanephrines (uMNs) whose reliability is well established to detect of pheochromocytoma. A total of 101 Japanese subjects clinically suspected of having pheochromocytoma in were included in this study. Subsequently, we prospectively measured the PFMs levels in all patients, compared with those of biochemical markers of the catecholamine secretion and metabolisms in the plasma and urine. All subjects with adrenal tumors underwent tumor excision. Data were available for 84 of the 101 patients, 47 of whom had histopathologically proven pheochromocytoma and 37 were finally diagnosed with non-pheochromocytoma. The results of comparisons in the accuracy of measurement for diagnosis of pheochromocytoma between PFMs and the urinary excretion of metanephrines (uMNs) were 0.980 VS 0.951 for AUC of receiver operatorating characteristic (ROC) curve, 0.957 VS 0.894 for sensitivity, and 0.973 VS 0.946 for specificity, respectively. Although the differences were small, the results of our study definitely demonstrated that measurement of PFMs was not inferior to standard urinary metanephrines (uMNs) measurement, which is established to be the most reliable biochemical method to detect pheochromocytoma. This study clearly shows measuring the PFMs levels to be a reliable and efficient method for diagnosing pheochromocytoma in Japanese patients, as demonstrated in previous reports. |
| doi_str_mv | 10.1507/endocrj.EJ13-0277 |
| format | Article |
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As this test has not yet been evaluated in Japan, it is necessary to evaluate the diagnostic efficacy of measuring the levels of PFMs compared with the standard measurement of the urinary excretion of metanephrines (uMNs) whose reliability is well established to detect of pheochromocytoma. A total of 101 Japanese subjects clinically suspected of having pheochromocytoma in were included in this study. Subsequently, we prospectively measured the PFMs levels in all patients, compared with those of biochemical markers of the catecholamine secretion and metabolisms in the plasma and urine. All subjects with adrenal tumors underwent tumor excision. Data were available for 84 of the 101 patients, 47 of whom had histopathologically proven pheochromocytoma and 37 were finally diagnosed with non-pheochromocytoma. The results of comparisons in the accuracy of measurement for diagnosis of pheochromocytoma between PFMs and the urinary excretion of metanephrines (uMNs) were 0.980 VS 0.951 for AUC of receiver operatorating characteristic (ROC) curve, 0.957 VS 0.894 for sensitivity, and 0.973 VS 0.946 for specificity, respectively. Although the differences were small, the results of our study definitely demonstrated that measurement of PFMs was not inferior to standard urinary metanephrines (uMNs) measurement, which is established to be the most reliable biochemical method to detect pheochromocytoma. This study clearly shows measuring the PFMs levels to be a reliable and efficient method for diagnosing pheochromocytoma in Japanese patients, as demonstrated in previous reports.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.EJ13-0277</identifier><identifier>PMID: 24871964</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Adrenal Gland Neoplasms - blood ; Adrenal Gland Neoplasms - diagnosis ; Adrenal Gland Neoplasms - pathology ; Adrenal Gland Neoplasms - urine ; Adrenal Glands - pathology ; Adult ; Area under curve (AUC) ; Biomarkers - blood ; Biomarkers - chemistry ; Biomarkers - urine ; Cohort Studies ; Diagnostic accuracy ; Female ; Hospitals, Municipal ; Hospitals, University ; Humans ; Immunoenzyme Techniques ; Japan ; Male ; Metanephrine - blood ; Metanephrine - chemistry ; Metanephrine - urine ; Middle Aged ; Normetanephrine - blood ; Normetanephrine - chemistry ; Normetanephrine - urine ; Pheochromocytoma ; Pheochromocytoma - blood ; Pheochromocytoma - diagnosis ; Pheochromocytoma - pathology ; Pheochromocytoma - urine ; Plasma free metanephrines (PFMs) ; Prospective Studies ; Sensitivity and Specificity ; Solubility ; Urinary metanephrines (uNMs) ; Vanilmandelic Acid - urine</subject><ispartof>Endocrine Journal, 2014, Vol.61(7), pp.667-673</ispartof><rights>The Japan Endocrine 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Yuji</creatorcontrib><creatorcontrib>Sakurai, Akihiro</creatorcontrib><creatorcontrib>Midorikawa, Sanae</creatorcontrib><creatorcontrib>Hataya, Yuji</creatorcontrib><creatorcontrib>Kato, Taiya</creatorcontrib><creatorcontrib>Kamide, Kei</creatorcontrib><creatorcontrib>Ikeda, Yukihiro</creatorcontrib><creatorcontrib>Okada, Yosuke</creatorcontrib><creatorcontrib>Adachi, Masahiro</creatorcontrib><creatorcontrib>Yanase, Toshihiko</creatorcontrib><creatorcontrib>Takahashi, Hideto</creatorcontrib><creatorcontrib>Yokoyama, Chie</creatorcontrib><creatorcontrib>Arai, Yusuke</creatorcontrib><creatorcontrib>Hashimoto, Koichi</creatorcontrib><creatorcontrib>Shimano, Hitoshi</creatorcontrib><creatorcontrib>Hara, Hisato</creatorcontrib><creatorcontrib>Kawakami, Yasushi</creatorcontrib><creatorcontrib>Takekoshi, Kazuhiro</creatorcontrib><creatorcontrib>Kyoto City Hospital</creatorcontrib><creatorcontrib>Osaka University Graduate School of Medicine</creatorcontrib><creatorcontrib>Department of Endocrinology and Metabolism</creatorcontrib><creatorcontrib>Fukushima Medical University</creatorcontrib><creatorcontrib>Nihon University School of Medicine</creatorcontrib><creatorcontrib>Kyushu University</creatorcontrib><creatorcontrib>Department of Laboratory Medicine</creatorcontrib><creatorcontrib>Kanazawa University Graduate School of Medical Sciences</creatorcontrib><creatorcontrib>Department of Medicine and Bioregulatory Science</creatorcontrib><creatorcontrib>Department of Breast and Endocrine Surgery</creatorcontrib><creatorcontrib>Department of Internal Medicine</creatorcontrib><creatorcontrib>Aichi Medical University</creatorcontrib><creatorcontrib>Aichi Koseiren Toyota Kosei Hospital</creatorcontrib><creatorcontrib>Japan</creatorcontrib><creatorcontrib>University of Tsukuba</creatorcontrib><creatorcontrib>Tsukuba Critical Path Research and Education Integrated Leading (CREIL Center</creatorcontrib><creatorcontrib>School of Medicine University of Occupational and Environmental Health</creatorcontrib><creatorcontrib>Department of Endocrinology</creatorcontrib><creatorcontrib>Nagoya University Hospital</creatorcontrib><creatorcontrib>Division of Nephrology</creatorcontrib><creatorcontrib>Sapporo Medical University School of Medicine</creatorcontrib><creatorcontrib>Kansai Medical University</creatorcontrib><creatorcontrib>Graduate School of Medical Sciences</creatorcontrib><creatorcontrib>Faculty of Medicine</creatorcontrib><creatorcontrib>Department of Endocrinology and Diabetes Mellitus</creatorcontrib><creatorcontrib>Department of Surgery</creatorcontrib><creatorcontrib>Department of Integrative Cancer Therapy and Urology</creatorcontrib><creatorcontrib>Biostatistics Office</creatorcontrib><creatorcontrib>University of Tsukuba Hospital</creatorcontrib><creatorcontrib>Division of Sports Science</creatorcontrib><creatorcontrib>Department of Urology and Andrology</creatorcontrib><creatorcontrib>Division of Health Sciences</creatorcontrib><creatorcontrib>Division of Laboratory</creatorcontrib><creatorcontrib>Tsukuba Critical Path Research and Education Integrated Leading Center (CREIL</creatorcontrib><creatorcontrib>Division of Breast and Endocrine Surgery</creatorcontrib><creatorcontrib>Department of Medical Genetics</creatorcontrib><creatorcontrib>The First Department of Internal Medicine</creatorcontrib><creatorcontrib>Department of Radiation Health Management</creatorcontrib><creatorcontrib>Fukuoka University</creatorcontrib><creatorcontrib>Hypertension and Endocrinology</creatorcontrib><title>Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description>Measuring the levels of the plasma free metanephrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe. As this test has not yet been evaluated in Japan, it is necessary to evaluate the diagnostic efficacy of measuring the levels of PFMs compared with the standard measurement of the urinary excretion of metanephrines (uMNs) whose reliability is well established to detect of pheochromocytoma. A total of 101 Japanese subjects clinically suspected of having pheochromocytoma in were included in this study. Subsequently, we prospectively measured the PFMs levels in all patients, compared with those of biochemical markers of the catecholamine secretion and metabolisms in the plasma and urine. All subjects with adrenal tumors underwent tumor excision. Data were available for 84 of the 101 patients, 47 of whom had histopathologically proven pheochromocytoma and 37 were finally diagnosed with non-pheochromocytoma. The results of comparisons in the accuracy of measurement for diagnosis of pheochromocytoma between PFMs and the urinary excretion of metanephrines (uMNs) were 0.980 VS 0.951 for AUC of receiver operatorating characteristic (ROC) curve, 0.957 VS 0.894 for sensitivity, and 0.973 VS 0.946 for specificity, respectively. Although the differences were small, the results of our study definitely demonstrated that measurement of PFMs was not inferior to standard urinary metanephrines (uMNs) measurement, which is established to be the most reliable biochemical method to detect pheochromocytoma. This study clearly shows measuring the PFMs levels to be a reliable and efficient method for diagnosing pheochromocytoma in Japanese patients, as demonstrated in previous reports.</description><subject>Adrenal Gland Neoplasms - blood</subject><subject>Adrenal Gland Neoplasms - diagnosis</subject><subject>Adrenal Gland Neoplasms - pathology</subject><subject>Adrenal Gland Neoplasms - urine</subject><subject>Adrenal Glands - pathology</subject><subject>Adult</subject><subject>Area under curve (AUC)</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - chemistry</subject><subject>Biomarkers - urine</subject><subject>Cohort Studies</subject><subject>Diagnostic accuracy</subject><subject>Female</subject><subject>Hospitals, Municipal</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Japan</subject><subject>Male</subject><subject>Metanephrine - blood</subject><subject>Metanephrine - chemistry</subject><subject>Metanephrine - urine</subject><subject>Middle Aged</subject><subject>Normetanephrine - blood</subject><subject>Normetanephrine - chemistry</subject><subject>Normetanephrine - urine</subject><subject>Pheochromocytoma</subject><subject>Pheochromocytoma - blood</subject><subject>Pheochromocytoma - diagnosis</subject><subject>Pheochromocytoma - pathology</subject><subject>Pheochromocytoma - urine</subject><subject>Plasma free metanephrines (PFMs)</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Solubility</subject><subject>Urinary metanephrines (uNMs)</subject><subject>Vanilmandelic Acid - urine</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE9v1DAQxS0EotvCB-CCfOSSYsf_Em6oKi1VJTjA2Zo6401WSZzaXon99njZbbh4LM2b37x5hHzg7JorZj7j3AUXd9e3D1xUrDbmFdlwIZtKKslekw1reVM1rWovyGVKO8aEUFK8JRe1bAxvtdyQPz9HSBNQHxHphBlmXPo4zJjoMNPcI-0G2M4hDYkGT5ceg-tjmII75DDBl5d2HhwF5_YR3IHC3NGUI2TcDgXkQ6QPsBR0QrpAHnDO6R1542FM-P5cr8jvb7e_bu6rxx9332--PlZOa5Er0KIxugGuavCaa_Ae0BjuufbcYWlpVE5xZhpl1BNr29bUXSe6TionlRJX5NOJu8TwvMeU7TQkh-NY7IR9slyV4VoKJYqUn6QuhpQiervEYYJ4sJzZY-D2HLg9Bm6PgZeZj2f8_mnCbp14SbgI7k6C0h0cjGEeS7p2F_ZxLndb96z_UW3NuLSM6XJKKQWvdfloI2rBi0P9n7RLGba4roJYwh9xNae5NcdnNbkqXA-xyMRf3Cav7g</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Tanaka, Yuko</creator><creator>Isobe, Kazumasa</creator><creator>Ma, Enbo</creator><creator>Imai, Tsuneo</creator><creator>Kikumori, Toyone</creator><creator>Matsuda, Tadashi</creator><creator>Maeda, Yuji</creator><creator>Sakurai, Akihiro</creator><creator>Midorikawa, Sanae</creator><creator>Hataya, Yuji</creator><creator>Kato, Taiya</creator><creator>Kamide, Kei</creator><creator>Ikeda, Yukihiro</creator><creator>Okada, Yosuke</creator><creator>Adachi, Masahiro</creator><creator>Yanase, Toshihiko</creator><creator>Takahashi, Hideto</creator><creator>Yokoyama, Chie</creator><creator>Arai, Yusuke</creator><creator>Hashimoto, Koichi</creator><creator>Shimano, Hitoshi</creator><creator>Hara, Hisato</creator><creator>Kawakami, Yasushi</creator><creator>Takekoshi, Kazuhiro</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients</title><author>Tanaka, Yuko ; Isobe, Kazumasa ; Ma, Enbo ; Imai, Tsuneo ; Kikumori, Toyone ; Matsuda, Tadashi ; Maeda, Yuji ; Sakurai, Akihiro ; Midorikawa, Sanae ; Hataya, Yuji ; Kato, Taiya ; Kamide, Kei ; Ikeda, Yukihiro ; Okada, Yosuke ; Adachi, Masahiro ; Yanase, Toshihiko ; Takahashi, Hideto ; Yokoyama, Chie ; Arai, Yusuke ; Hashimoto, Koichi ; Shimano, Hitoshi ; Hara, Hisato ; Kawakami, Yasushi ; Takekoshi, Kazuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c663t-a638768a152af616affae771f16f1ce7686e5c51078575b099972dd3dd45c4553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adrenal Gland Neoplasms - blood</topic><topic>Adrenal Gland Neoplasms - diagnosis</topic><topic>Adrenal Gland Neoplasms - pathology</topic><topic>Adrenal Gland Neoplasms - urine</topic><topic>Adrenal Glands - pathology</topic><topic>Adult</topic><topic>Area under curve (AUC)</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - chemistry</topic><topic>Biomarkers - urine</topic><topic>Cohort Studies</topic><topic>Diagnostic accuracy</topic><topic>Female</topic><topic>Hospitals, Municipal</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Japan</topic><topic>Male</topic><topic>Metanephrine - blood</topic><topic>Metanephrine - chemistry</topic><topic>Metanephrine - urine</topic><topic>Middle Aged</topic><topic>Normetanephrine - blood</topic><topic>Normetanephrine - chemistry</topic><topic>Normetanephrine - urine</topic><topic>Pheochromocytoma</topic><topic>Pheochromocytoma - blood</topic><topic>Pheochromocytoma - diagnosis</topic><topic>Pheochromocytoma - pathology</topic><topic>Pheochromocytoma - urine</topic><topic>Plasma free metanephrines (PFMs)</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Solubility</topic><topic>Urinary metanephrines (uNMs)</topic><topic>Vanilmandelic Acid - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Yuko</creatorcontrib><creatorcontrib>Isobe, Kazumasa</creatorcontrib><creatorcontrib>Ma, Enbo</creatorcontrib><creatorcontrib>Imai, Tsuneo</creatorcontrib><creatorcontrib>Kikumori, Toyone</creatorcontrib><creatorcontrib>Matsuda, Tadashi</creatorcontrib><creatorcontrib>Maeda, Yuji</creatorcontrib><creatorcontrib>Sakurai, Akihiro</creatorcontrib><creatorcontrib>Midorikawa, Sanae</creatorcontrib><creatorcontrib>Hataya, Yuji</creatorcontrib><creatorcontrib>Kato, Taiya</creatorcontrib><creatorcontrib>Kamide, Kei</creatorcontrib><creatorcontrib>Ikeda, Yukihiro</creatorcontrib><creatorcontrib>Okada, Yosuke</creatorcontrib><creatorcontrib>Adachi, Masahiro</creatorcontrib><creatorcontrib>Yanase, Toshihiko</creatorcontrib><creatorcontrib>Takahashi, Hideto</creatorcontrib><creatorcontrib>Yokoyama, Chie</creatorcontrib><creatorcontrib>Arai, Yusuke</creatorcontrib><creatorcontrib>Hashimoto, Koichi</creatorcontrib><creatorcontrib>Shimano, Hitoshi</creatorcontrib><creatorcontrib>Hara, Hisato</creatorcontrib><creatorcontrib>Kawakami, Yasushi</creatorcontrib><creatorcontrib>Takekoshi, Kazuhiro</creatorcontrib><creatorcontrib>Kyoto City Hospital</creatorcontrib><creatorcontrib>Osaka University Graduate School of Medicine</creatorcontrib><creatorcontrib>Department of Endocrinology and Metabolism</creatorcontrib><creatorcontrib>Fukushima Medical University</creatorcontrib><creatorcontrib>Nihon University School of Medicine</creatorcontrib><creatorcontrib>Kyushu University</creatorcontrib><creatorcontrib>Department of Laboratory Medicine</creatorcontrib><creatorcontrib>Kanazawa University Graduate School of Medical Sciences</creatorcontrib><creatorcontrib>Department of Medicine and Bioregulatory Science</creatorcontrib><creatorcontrib>Department of Breast and Endocrine Surgery</creatorcontrib><creatorcontrib>Department of Internal Medicine</creatorcontrib><creatorcontrib>Aichi Medical University</creatorcontrib><creatorcontrib>Aichi Koseiren Toyota Kosei Hospital</creatorcontrib><creatorcontrib>Japan</creatorcontrib><creatorcontrib>University of Tsukuba</creatorcontrib><creatorcontrib>Tsukuba Critical Path Research and Education Integrated Leading (CREIL Center</creatorcontrib><creatorcontrib>School of Medicine University of Occupational and Environmental Health</creatorcontrib><creatorcontrib>Department of Endocrinology</creatorcontrib><creatorcontrib>Nagoya University Hospital</creatorcontrib><creatorcontrib>Division of Nephrology</creatorcontrib><creatorcontrib>Sapporo Medical University School of Medicine</creatorcontrib><creatorcontrib>Kansai Medical University</creatorcontrib><creatorcontrib>Graduate School of Medical Sciences</creatorcontrib><creatorcontrib>Faculty of Medicine</creatorcontrib><creatorcontrib>Department of Endocrinology and Diabetes Mellitus</creatorcontrib><creatorcontrib>Department of Surgery</creatorcontrib><creatorcontrib>Department of Integrative Cancer Therapy and Urology</creatorcontrib><creatorcontrib>Biostatistics Office</creatorcontrib><creatorcontrib>University of Tsukuba Hospital</creatorcontrib><creatorcontrib>Division of Sports Science</creatorcontrib><creatorcontrib>Department of Urology and Andrology</creatorcontrib><creatorcontrib>Division of Health Sciences</creatorcontrib><creatorcontrib>Division of Laboratory</creatorcontrib><creatorcontrib>Tsukuba Critical Path Research and Education Integrated Leading Center (CREIL</creatorcontrib><creatorcontrib>Division of Breast and Endocrine Surgery</creatorcontrib><creatorcontrib>Department of Medical Genetics</creatorcontrib><creatorcontrib>The First Department of Internal Medicine</creatorcontrib><creatorcontrib>Department of Radiation Health Management</creatorcontrib><creatorcontrib>Fukuoka University</creatorcontrib><creatorcontrib>Hypertension and Endocrinology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Yuko</au><au>Isobe, Kazumasa</au><au>Ma, Enbo</au><au>Imai, Tsuneo</au><au>Kikumori, Toyone</au><au>Matsuda, Tadashi</au><au>Maeda, Yuji</au><au>Sakurai, Akihiro</au><au>Midorikawa, Sanae</au><au>Hataya, Yuji</au><au>Kato, Taiya</au><au>Kamide, Kei</au><au>Ikeda, Yukihiro</au><au>Okada, Yosuke</au><au>Adachi, Masahiro</au><au>Yanase, Toshihiko</au><au>Takahashi, Hideto</au><au>Yokoyama, Chie</au><au>Arai, Yusuke</au><au>Hashimoto, Koichi</au><au>Shimano, Hitoshi</au><au>Hara, Hisato</au><au>Kawakami, Yasushi</au><au>Takekoshi, Kazuhiro</au><aucorp>Kyoto City Hospital</aucorp><aucorp>Osaka University Graduate School of Medicine</aucorp><aucorp>Department of Endocrinology and Metabolism</aucorp><aucorp>Fukushima Medical University</aucorp><aucorp>Nihon University School of Medicine</aucorp><aucorp>Kyushu University</aucorp><aucorp>Department of Laboratory Medicine</aucorp><aucorp>Kanazawa University Graduate School of Medical Sciences</aucorp><aucorp>Department of Medicine and Bioregulatory Science</aucorp><aucorp>Department of Breast and Endocrine Surgery</aucorp><aucorp>Department of Internal Medicine</aucorp><aucorp>Aichi Medical University</aucorp><aucorp>Aichi Koseiren Toyota Kosei Hospital</aucorp><aucorp>Japan</aucorp><aucorp>University of Tsukuba</aucorp><aucorp>Tsukuba Critical Path Research and Education Integrated Leading (CREIL Center</aucorp><aucorp>School of Medicine University of Occupational and Environmental Health</aucorp><aucorp>Department of Endocrinology</aucorp><aucorp>Nagoya University Hospital</aucorp><aucorp>Division of Nephrology</aucorp><aucorp>Sapporo Medical University School of Medicine</aucorp><aucorp>Kansai Medical University</aucorp><aucorp>Graduate School of Medical Sciences</aucorp><aucorp>Faculty of Medicine</aucorp><aucorp>Department of Endocrinology and Diabetes Mellitus</aucorp><aucorp>Department of Surgery</aucorp><aucorp>Department of Integrative Cancer Therapy and Urology</aucorp><aucorp>Biostatistics Office</aucorp><aucorp>University of Tsukuba Hospital</aucorp><aucorp>Division of Sports Science</aucorp><aucorp>Department of Urology and Andrology</aucorp><aucorp>Division of Health Sciences</aucorp><aucorp>Division of Laboratory</aucorp><aucorp>Tsukuba Critical Path Research and Education Integrated Leading Center (CREIL</aucorp><aucorp>Division of Breast and Endocrine Surgery</aucorp><aucorp>Department of Medical Genetics</aucorp><aucorp>The First Department of Internal Medicine</aucorp><aucorp>Department of Radiation Health Management</aucorp><aucorp>Fukuoka University</aucorp><aucorp>Hypertension and Endocrinology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>2014</date><risdate>2014</risdate><volume>61</volume><issue>7</issue><spage>667</spage><epage>673</epage><pages>667-673</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>Measuring the levels of the plasma free metanephrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe. As this test has not yet been evaluated in Japan, it is necessary to evaluate the diagnostic efficacy of measuring the levels of PFMs compared with the standard measurement of the urinary excretion of metanephrines (uMNs) whose reliability is well established to detect of pheochromocytoma. A total of 101 Japanese subjects clinically suspected of having pheochromocytoma in were included in this study. Subsequently, we prospectively measured the PFMs levels in all patients, compared with those of biochemical markers of the catecholamine secretion and metabolisms in the plasma and urine. All subjects with adrenal tumors underwent tumor excision. Data were available for 84 of the 101 patients, 47 of whom had histopathologically proven pheochromocytoma and 37 were finally diagnosed with non-pheochromocytoma. The results of comparisons in the accuracy of measurement for diagnosis of pheochromocytoma between PFMs and the urinary excretion of metanephrines (uMNs) were 0.980 VS 0.951 for AUC of receiver operatorating characteristic (ROC) curve, 0.957 VS 0.894 for sensitivity, and 0.973 VS 0.946 for specificity, respectively. Although the differences were small, the results of our study definitely demonstrated that measurement of PFMs was not inferior to standard urinary metanephrines (uMNs) measurement, which is established to be the most reliable biochemical method to detect pheochromocytoma. This study clearly shows measuring the PFMs levels to be a reliable and efficient method for diagnosing pheochromocytoma in Japanese patients, as demonstrated in previous reports.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>24871964</pmid><doi>10.1507/endocrj.EJ13-0277</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-8959 |
| ispartof | Endocrine Journal, 2014, Vol.61(7), pp.667-673 |
| issn | 0918-8959 1348-4540 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1551024353 |
| source | MEDLINE; J-STAGE日本語サイト (Free Access); Free E-Journal (出版社公開部分のみ） |
| subjects | Adrenal Gland Neoplasms - blood Adrenal Gland Neoplasms - diagnosis Adrenal Gland Neoplasms - pathology Adrenal Gland Neoplasms - urine Adrenal Glands - pathology Adult Area under curve (AUC) Biomarkers - blood Biomarkers - chemistry Biomarkers - urine Cohort Studies Diagnostic accuracy Female Hospitals, Municipal Hospitals, University Humans Immunoenzyme Techniques Japan Male Metanephrine - blood Metanephrine - chemistry Metanephrine - urine Middle Aged Normetanephrine - blood Normetanephrine - chemistry Normetanephrine - urine Pheochromocytoma Pheochromocytoma - blood Pheochromocytoma - diagnosis Pheochromocytoma - pathology Pheochromocytoma - urine Plasma free metanephrines (PFMs) Prospective Studies Sensitivity and Specificity Solubility Urinary metanephrines (uNMs) Vanilmandelic Acid - urine |
| title | Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients |
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