OxLDL Triggers Retrograde Translocation of Arginase2 in Aortic Endothelial Cells via ROCK and Mitochondrial Processing Peptidase

RATIONALE:Increased arginase activity contributes to endothelial dysfunction by competition for L-arginine substrate and reciprocal regulation of nitric oxide synthase (NOS). The rapid increase in arginase activity in human aortic endothelial cells exposed to oxidized low-density lipoprotein (OxLDL)...

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Veröffentlicht in:	Circulation research 2014-08, Vol.115 (4), p.450-459
Hauptverfasser:	Pandey, Deepesh, Bhunia, Anil, Oh, Young Jun, Chang, Fumin, Bergman, Yehudit, Kim, Jae Hyung, Serbo, Janna, Boronina, Tatiana N, Cole, Robert N, Van Eyk, Jennifer, Remaley, Alan T, Berkowitz, Dan E, Romer, Lewis H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aorta - drug effects Aorta - enzymology Aorta - pathology Aorta - physiopathology Aortic Diseases - enzymology Aortic Diseases - genetics Aortic Diseases - pathology Aortic Diseases - physiopathology Aortic Diseases - prevention & control Apolipoproteins E - deficiency Apolipoproteins E - genetics Arginase - genetics Arginase - metabolism Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - pathology Atherosclerosis - physiopathology Atherosclerosis - prevention & control Cells, Cultured Cytosol - enzymology Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - enzymology Enzyme Activation Humans Lipoproteins, LDL - metabolism Male Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mitochondria - drug effects Mitochondria - enzymology Mitochondrial Processing Peptidase Molecular Sequence Data Protein Kinase Inhibitors - pharmacology Protein Transport rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism RNA Interference Scavenger Receptors, Class E - deficiency Scavenger Receptors, Class E - genetics Signal Transduction Time Factors Transfection
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