Comparison of the Clinical Disc Margin Seen in Stereo Disc Photographs With Neural Canal Opening Seen in Optical Coherence Tomography Images

PURPOSE:To compare neural canal opening (NCO) with the clinical optic disc margin (DM) seen and to investigate the planarity of the NCO in normal human optic nerve heads (ONH). METHODS:Sixteen eyes were imaged. Twelve healthy eyes were selected for planarity and 9 for NCO and DM correspondence. All...

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Veröffentlicht in:Journal of glaucoma 2014-08, Vol.23 (6), p.360-367
Hauptverfasser: Young, Mei, Lee, Sieun, Rateb, Mahmoud, Beg, Mirza F, Sarunic, Marinko V, Mackenzie, Paul J
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container_end_page 367
container_issue 6
container_start_page 360
container_title Journal of glaucoma
container_volume 23
creator Young, Mei
Lee, Sieun
Rateb, Mahmoud
Beg, Mirza F
Sarunic, Marinko V
Mackenzie, Paul J
description PURPOSE:To compare neural canal opening (NCO) with the clinical optic disc margin (DM) seen and to investigate the planarity of the NCO in normal human optic nerve heads (ONH). METHODS:Sixteen eyes were imaged. Twelve healthy eyes were selected for planarity and 9 for NCO and DM correspondence. All subjects were subjected to a visual field examination, stereo disc photograph (SDP), scanning laser ophthalmoscopy, clinical examination with a fellowship trained glaucoma specialist, and optical coherence tomography imaging. Three reviewers delineated the NCO and inner limiting membrane on optical coherence tomography images. The clinical DM was delineated by a glaucoma specialist while viewing SDPs. Plane error was calculated for NCO and for Bruch membrane (BM) at distances 80 and 120 μm from NCO. RESULTS:The NCO segmentation interrater variability was low with an average coefficient of variation of 2.7%. A regional variation of the SDP and NCO correspondence was observed, wherein the temporal region had the largest coefficient of variation. The plane error of the NCO and BM were similar and was approximately 12 μm, which is small relative to an average DM diameter of 1.7 mm. CONCLUSIONS:The BM opening has a good correspondence with the clinical DM seen in SDPs. NCO delineation seemed to be reliable. The BM and NCO are relatively planar in normal humans and can be further evaluated for longitudinal studies to observe stability.
doi_str_mv 10.1097/IJG.0b013e31829484a4
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METHODS:Sixteen eyes were imaged. Twelve healthy eyes were selected for planarity and 9 for NCO and DM correspondence. All subjects were subjected to a visual field examination, stereo disc photograph (SDP), scanning laser ophthalmoscopy, clinical examination with a fellowship trained glaucoma specialist, and optical coherence tomography imaging. Three reviewers delineated the NCO and inner limiting membrane on optical coherence tomography images. The clinical DM was delineated by a glaucoma specialist while viewing SDPs. Plane error was calculated for NCO and for Bruch membrane (BM) at distances 80 and 120 μm from NCO. RESULTS:The NCO segmentation interrater variability was low with an average coefficient of variation of 2.7%. A regional variation of the SDP and NCO correspondence was observed, wherein the temporal region had the largest coefficient of variation. The plane error of the NCO and BM were similar and was approximately 12 μm, which is small relative to an average DM diameter of 1.7 mm. CONCLUSIONS:The BM opening has a good correspondence with the clinical DM seen in SDPs. NCO delineation seemed to be reliable. The BM and NCO are relatively planar in normal humans and can be further evaluated for longitudinal studies to observe stability.</description><identifier>ISSN: 1057-0829</identifier><identifier>EISSN: 1536-481X</identifier><identifier>DOI: 10.1097/IJG.0b013e31829484a4</identifier><identifier>PMID: 25075462</identifier><language>eng</language><publisher>United States: by Lippincott Williams &amp; Wilkins</publisher><subject>Adolescent ; Adult ; Bruch Membrane - anatomy &amp; histology ; Female ; Humans ; Imaging, Three-Dimensional ; Longitudinal Studies ; Male ; Neural Tube - anatomy &amp; histology ; Ophthalmoscopy ; Optic Disk - anatomy &amp; histology ; Photography ; Retinal Pigment Epithelium - cytology ; Tomography, Optical Coherence - methods ; Visual Fields - physiology ; Young Adult</subject><ispartof>Journal of glaucoma, 2014-08, Vol.23 (6), p.360-367</ispartof><rights>2014 by Lippincott Williams &amp; Wilkins.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3526-29f5a6cfa51ce65f1dd842c19a706a889a78fc9b8d486ab8b3b452f5911418103</citedby><cites>FETCH-LOGICAL-c3526-29f5a6cfa51ce65f1dd842c19a706a889a78fc9b8d486ab8b3b452f5911418103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25075462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Young, Mei</creatorcontrib><creatorcontrib>Lee, Sieun</creatorcontrib><creatorcontrib>Rateb, Mahmoud</creatorcontrib><creatorcontrib>Beg, Mirza F</creatorcontrib><creatorcontrib>Sarunic, Marinko V</creatorcontrib><creatorcontrib>Mackenzie, Paul J</creatorcontrib><title>Comparison of the Clinical Disc Margin Seen in Stereo Disc Photographs With Neural Canal Opening Seen in Optical Coherence Tomography Images</title><title>Journal of glaucoma</title><addtitle>J Glaucoma</addtitle><description>PURPOSE:To compare neural canal opening (NCO) with the clinical optic disc margin (DM) seen and to investigate the planarity of the NCO in normal human optic nerve heads (ONH). METHODS:Sixteen eyes were imaged. Twelve healthy eyes were selected for planarity and 9 for NCO and DM correspondence. All subjects were subjected to a visual field examination, stereo disc photograph (SDP), scanning laser ophthalmoscopy, clinical examination with a fellowship trained glaucoma specialist, and optical coherence tomography imaging. Three reviewers delineated the NCO and inner limiting membrane on optical coherence tomography images. The clinical DM was delineated by a glaucoma specialist while viewing SDPs. Plane error was calculated for NCO and for Bruch membrane (BM) at distances 80 and 120 μm from NCO. RESULTS:The NCO segmentation interrater variability was low with an average coefficient of variation of 2.7%. A regional variation of the SDP and NCO correspondence was observed, wherein the temporal region had the largest coefficient of variation. The plane error of the NCO and BM were similar and was approximately 12 μm, which is small relative to an average DM diameter of 1.7 mm. CONCLUSIONS:The BM opening has a good correspondence with the clinical DM seen in SDPs. NCO delineation seemed to be reliable. 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METHODS:Sixteen eyes were imaged. Twelve healthy eyes were selected for planarity and 9 for NCO and DM correspondence. All subjects were subjected to a visual field examination, stereo disc photograph (SDP), scanning laser ophthalmoscopy, clinical examination with a fellowship trained glaucoma specialist, and optical coherence tomography imaging. Three reviewers delineated the NCO and inner limiting membrane on optical coherence tomography images. The clinical DM was delineated by a glaucoma specialist while viewing SDPs. Plane error was calculated for NCO and for Bruch membrane (BM) at distances 80 and 120 μm from NCO. RESULTS:The NCO segmentation interrater variability was low with an average coefficient of variation of 2.7%. A regional variation of the SDP and NCO correspondence was observed, wherein the temporal region had the largest coefficient of variation. The plane error of the NCO and BM were similar and was approximately 12 μm, which is small relative to an average DM diameter of 1.7 mm. CONCLUSIONS:The BM opening has a good correspondence with the clinical DM seen in SDPs. NCO delineation seemed to be reliable. The BM and NCO are relatively planar in normal humans and can be further evaluated for longitudinal studies to observe stability.</abstract><cop>United States</cop><pub>by Lippincott Williams &amp; Wilkins</pub><pmid>25075462</pmid><doi>10.1097/IJG.0b013e31829484a4</doi><tpages>8</tpages></addata></record>
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subjects Adolescent
Adult
Bruch Membrane - anatomy & histology
Female
Humans
Imaging, Three-Dimensional
Longitudinal Studies
Male
Neural Tube - anatomy & histology
Ophthalmoscopy
Optic Disk - anatomy & histology
Photography
Retinal Pigment Epithelium - cytology
Tomography, Optical Coherence - methods
Visual Fields - physiology
Young Adult
title Comparison of the Clinical Disc Margin Seen in Stereo Disc Photographs With Neural Canal Opening Seen in Optical Coherence Tomography Images
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