Use of sevelamer to examine the role of intraluminal phosphate in the pathogenesis of secondary hyperparathyroidism

Parathyroid hormone (PTH) promotes calcium reabsorption in the cortical distal nephron (CDN). The phosphate concentration ([P]f) rises in that segment in chronic kidney disease (CKD); in theory, high [P]f could reduce availability of calcium for reabsorption and necessitate a compensatory rise in [P...

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Veröffentlicht in:	Clinical nephrology 2014-09, Vol.82 (3), p.191-201
Hauptverfasser:	Phelps, Kenneth R, Stote, Kim S, Mason, Darius
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers - blood Calcium - blood Chelating Agents - therapeutic use Female Fibroblast Growth Factors - blood Glomerular Filtration Rate Humans Hyperparathyroidism, Secondary - blood Hyperparathyroidism, Secondary - drug therapy Hyperparathyroidism, Secondary - etiology Hyperparathyroidism, Secondary - physiopathology Kidney - drug effects Kidney - metabolism Linear Models Male Middle Aged Models, Biological Parathyroid Hormone - blood Phosphates - blood Polyamines - therapeutic use Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - physiopathology Sevelamer Time Factors Treatment Outcome Vitamin D - analogs & derivatives Vitamin D - blood
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