Erythropoietin administration facilitates return of spontaneous circulation and improves survival in a pig model of cardiac arrest
Abstract Background In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. However, its role in the cardiac arrest (CA) setting has not yet been adequately inv...
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| Veröffentlicht in: | The American journal of emergency medicine 2014-08, Vol.32 (8), p.871-877 |
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| creator | Vasileiou, Panagiotis V.S., MSc Xanthos, Theodoros, PhD Barouxis, Dimitrios, MSc Pantazopoulos, Charalampos, MD Papalois, Apostolos E., PhD Lelovas, Paulos, PhD Kotsilianou, Olympia, MD Pliatsika, Paraskevi, MSc Kouskouni, Evaggelia, PhD Iacovidou, Nicoletta, PhD |
| description | Abstract Background In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. However, its role in the cardiac arrest (CA) setting has not yet been adequately investigated. Aim The aim of this study is to examine the effect of rh-EPO in a pig model of ventricular fibrillation (VF)-induced CA. Methods Ventricular fibrillation was electrically induced in 20 piglets and maintained untreated for 8 minutes before attempting resuscitation. Animals were randomized to receive rh-EPO (5000 IU/kg, erythropoietin [EPO] group, n = 10) immediately before the initiation of chest compressions or to receive 0.9% Sodium chloride solution instead (control group, n = 10). Results Compared with the control, the EPO group had higher rates of return of spontaneous circulation (ROSC) (100% vs 60%, P = .011) and higher 48-hour survival (100% vs 40%, P = .001). Diastolic aortic pressure and coronary perfusion pressure during cardiopulmonary resuscitation were significantly higher in the EPO group compared with the control group. Erythropoietin-treated animals required fewer number of shocks in comparison with animals that received normal saline ( P = .04). Furthermore, the neurologic alertness score was higher in the EPO group compared with that of the control group at 24 ( P = .004) and 48 hours ( P = .021). Conclusion Administration of rh-EPO in a pig model of VF-induced CA just before reperfusion facilitates ROSC and improves survival rates as well as hemodynamic variables. |
| doi_str_mv | 10.1016/j.ajem.2014.04.036 |
| format | Article |
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However, its role in the cardiac arrest (CA) setting has not yet been adequately investigated. Aim The aim of this study is to examine the effect of rh-EPO in a pig model of ventricular fibrillation (VF)-induced CA. Methods Ventricular fibrillation was electrically induced in 20 piglets and maintained untreated for 8 minutes before attempting resuscitation. Animals were randomized to receive rh-EPO (5000 IU/kg, erythropoietin [EPO] group, n = 10) immediately before the initiation of chest compressions or to receive 0.9% Sodium chloride solution instead (control group, n = 10). Results Compared with the control, the EPO group had higher rates of return of spontaneous circulation (ROSC) (100% vs 60%, P = .011) and higher 48-hour survival (100% vs 40%, P = .001). Diastolic aortic pressure and coronary perfusion pressure during cardiopulmonary resuscitation were significantly higher in the EPO group compared with the control group. Erythropoietin-treated animals required fewer number of shocks in comparison with animals that received normal saline ( P = .04). Furthermore, the neurologic alertness score was higher in the EPO group compared with that of the control group at 24 ( P = .004) and 48 hours ( P = .021). Conclusion Administration of rh-EPO in a pig model of VF-induced CA just before reperfusion facilitates ROSC and improves survival rates as well as hemodynamic variables.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2014.04.036</identifier><identifier>PMID: 24857249</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Blood Circulation - drug effects ; Blood Pressure - drug effects ; Brain research ; Cardiac arrest ; Cardiopulmonary Resuscitation ; CPR ; Disease Models, Animal ; Emergency ; Emergency medical care ; Erythropoietin - therapeutic use ; Female ; Free radicals ; Heart Arrest - drug therapy ; Heart Arrest - etiology ; Hogs ; Sodium chloride ; Survival ; Swine ; Treatment Outcome ; Ventilators ; Ventricular Fibrillation - complications</subject><ispartof>The American journal of emergency medicine, 2014-08, Vol.32 (8), p.871-877</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-c84cc25edb4c25a537c9524f2ecf353eade6ba51e570f159680d3b2cb079f1593</citedby><cites>FETCH-LOGICAL-c509t-c84cc25edb4c25a537c9524f2ecf353eade6ba51e570f159680d3b2cb079f1593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735675714002800$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24857249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasileiou, Panagiotis V.S., MSc</creatorcontrib><creatorcontrib>Xanthos, Theodoros, PhD</creatorcontrib><creatorcontrib>Barouxis, Dimitrios, MSc</creatorcontrib><creatorcontrib>Pantazopoulos, Charalampos, MD</creatorcontrib><creatorcontrib>Papalois, Apostolos E., PhD</creatorcontrib><creatorcontrib>Lelovas, Paulos, PhD</creatorcontrib><creatorcontrib>Kotsilianou, Olympia, MD</creatorcontrib><creatorcontrib>Pliatsika, Paraskevi, MSc</creatorcontrib><creatorcontrib>Kouskouni, Evaggelia, PhD</creatorcontrib><creatorcontrib>Iacovidou, Nicoletta, PhD</creatorcontrib><title>Erythropoietin administration facilitates return of spontaneous circulation and improves survival in a pig model of cardiac arrest</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Abstract Background In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. However, its role in the cardiac arrest (CA) setting has not yet been adequately investigated. Aim The aim of this study is to examine the effect of rh-EPO in a pig model of ventricular fibrillation (VF)-induced CA. Methods Ventricular fibrillation was electrically induced in 20 piglets and maintained untreated for 8 minutes before attempting resuscitation. Animals were randomized to receive rh-EPO (5000 IU/kg, erythropoietin [EPO] group, n = 10) immediately before the initiation of chest compressions or to receive 0.9% Sodium chloride solution instead (control group, n = 10). Results Compared with the control, the EPO group had higher rates of return of spontaneous circulation (ROSC) (100% vs 60%, P = .011) and higher 48-hour survival (100% vs 40%, P = .001). Diastolic aortic pressure and coronary perfusion pressure during cardiopulmonary resuscitation were significantly higher in the EPO group compared with the control group. Erythropoietin-treated animals required fewer number of shocks in comparison with animals that received normal saline ( P = .04). Furthermore, the neurologic alertness score was higher in the EPO group compared with that of the control group at 24 ( P = .004) and 48 hours ( P = .021). Conclusion Administration of rh-EPO in a pig model of VF-induced CA just before reperfusion facilitates ROSC and improves survival rates as well as hemodynamic variables.</description><subject>Animals</subject><subject>Blood Circulation - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Brain research</subject><subject>Cardiac arrest</subject><subject>Cardiopulmonary Resuscitation</subject><subject>CPR</subject><subject>Disease Models, Animal</subject><subject>Emergency</subject><subject>Emergency medical care</subject><subject>Erythropoietin - therapeutic use</subject><subject>Female</subject><subject>Free radicals</subject><subject>Heart Arrest - drug therapy</subject><subject>Heart Arrest - etiology</subject><subject>Hogs</subject><subject>Sodium chloride</subject><subject>Survival</subject><subject>Swine</subject><subject>Treatment Outcome</subject><subject>Ventilators</subject><subject>Ventricular Fibrillation - complications</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9ksuKFTEQhoMoznH0BVxIwI2bPubaFxBhGMYLDLhQ1yGdVGva7k6bpA-crU9uQo8KsxAKisBXf6rqL4SeU3KkhNavx6MeYT4yQsWR5OD1A3SgkrOqpQ19iA6k4bKqG9lcoCcxjoRQKqR4jC6YaGXDRHdAv27COX0PfvUOkluwtrNbXExBJ-cXPGjjJpd0gogDpC0s2A84rn5JegG_RWxcMNu003qx2M1r8KeMxy2c3ElPuKji1X3Ds7cwlXqjg3XaYB0CxPQUPRr0FOHZXb5EX9_dfLn-UN1-ev_x-uq2MpJ0qTKtMIZJsL3ISUvemE4yMTAwA5cctIW615KCbMhAZVe3xPKemZ40XXnzS_Rq180N_tzyx2p20cA07ZMoKiUljJGmzujLe-jo8-y5u0yJtmU1pUWQ7ZQJPsYAg1qDm3U4K0pUcUiNqjikikOK5OBF-sWd9NbPYP-W_LEkA292APIuTg6CisbBYsC6ACYp693_9d_eKzdTdtTo6QecIf6bQ0WmiPpcbqScCBWEsJYQ_hu9OLmB</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Vasileiou, Panagiotis V.S., MSc</creator><creator>Xanthos, Theodoros, PhD</creator><creator>Barouxis, Dimitrios, MSc</creator><creator>Pantazopoulos, Charalampos, MD</creator><creator>Papalois, Apostolos E., PhD</creator><creator>Lelovas, Paulos, PhD</creator><creator>Kotsilianou, Olympia, MD</creator><creator>Pliatsika, Paraskevi, MSc</creator><creator>Kouskouni, Evaggelia, PhD</creator><creator>Iacovidou, Nicoletta, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Erythropoietin administration facilitates return of spontaneous circulation and improves survival in a pig model of cardiac arrest</title><author>Vasileiou, Panagiotis V.S., MSc ; Xanthos, Theodoros, PhD ; Barouxis, Dimitrios, MSc ; Pantazopoulos, Charalampos, MD ; Papalois, Apostolos E., PhD ; Lelovas, Paulos, PhD ; Kotsilianou, Olympia, MD ; Pliatsika, Paraskevi, MSc ; Kouskouni, Evaggelia, PhD ; Iacovidou, Nicoletta, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-c84cc25edb4c25a537c9524f2ecf353eade6ba51e570f159680d3b2cb079f1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Blood Circulation - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Brain research</topic><topic>Cardiac arrest</topic><topic>Cardiopulmonary Resuscitation</topic><topic>CPR</topic><topic>Disease Models, Animal</topic><topic>Emergency</topic><topic>Emergency medical care</topic><topic>Erythropoietin - therapeutic use</topic><topic>Female</topic><topic>Free radicals</topic><topic>Heart Arrest - drug therapy</topic><topic>Heart Arrest - etiology</topic><topic>Hogs</topic><topic>Sodium chloride</topic><topic>Survival</topic><topic>Swine</topic><topic>Treatment Outcome</topic><topic>Ventilators</topic><topic>Ventricular Fibrillation - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasileiou, Panagiotis V.S., MSc</creatorcontrib><creatorcontrib>Xanthos, Theodoros, PhD</creatorcontrib><creatorcontrib>Barouxis, Dimitrios, MSc</creatorcontrib><creatorcontrib>Pantazopoulos, Charalampos, MD</creatorcontrib><creatorcontrib>Papalois, Apostolos E., PhD</creatorcontrib><creatorcontrib>Lelovas, Paulos, PhD</creatorcontrib><creatorcontrib>Kotsilianou, Olympia, MD</creatorcontrib><creatorcontrib>Pliatsika, Paraskevi, MSc</creatorcontrib><creatorcontrib>Kouskouni, Evaggelia, PhD</creatorcontrib><creatorcontrib>Iacovidou, Nicoletta, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasileiou, Panagiotis V.S., MSc</au><au>Xanthos, Theodoros, PhD</au><au>Barouxis, Dimitrios, MSc</au><au>Pantazopoulos, Charalampos, MD</au><au>Papalois, Apostolos E., PhD</au><au>Lelovas, Paulos, PhD</au><au>Kotsilianou, Olympia, MD</au><au>Pliatsika, Paraskevi, MSc</au><au>Kouskouni, Evaggelia, PhD</au><au>Iacovidou, Nicoletta, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erythropoietin administration facilitates return of spontaneous circulation and improves survival in a pig model of cardiac arrest</atitle><jtitle>The American journal of emergency medicine</jtitle><addtitle>Am J Emerg Med</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>32</volume><issue>8</issue><spage>871</spage><epage>877</epage><pages>871-877</pages><issn>0735-6757</issn><eissn>1532-8171</eissn><abstract>Abstract Background In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. However, its role in the cardiac arrest (CA) setting has not yet been adequately investigated. Aim The aim of this study is to examine the effect of rh-EPO in a pig model of ventricular fibrillation (VF)-induced CA. Methods Ventricular fibrillation was electrically induced in 20 piglets and maintained untreated for 8 minutes before attempting resuscitation. Animals were randomized to receive rh-EPO (5000 IU/kg, erythropoietin [EPO] group, n = 10) immediately before the initiation of chest compressions or to receive 0.9% Sodium chloride solution instead (control group, n = 10). Results Compared with the control, the EPO group had higher rates of return of spontaneous circulation (ROSC) (100% vs 60%, P = .011) and higher 48-hour survival (100% vs 40%, P = .001). Diastolic aortic pressure and coronary perfusion pressure during cardiopulmonary resuscitation were significantly higher in the EPO group compared with the control group. Erythropoietin-treated animals required fewer number of shocks in comparison with animals that received normal saline ( P = .04). Furthermore, the neurologic alertness score was higher in the EPO group compared with that of the control group at 24 ( P = .004) and 48 hours ( P = .021). Conclusion Administration of rh-EPO in a pig model of VF-induced CA just before reperfusion facilitates ROSC and improves survival rates as well as hemodynamic variables.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24857249</pmid><doi>10.1016/j.ajem.2014.04.036</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Blood Circulation - drug effects Blood Pressure - drug effects Brain research Cardiac arrest Cardiopulmonary Resuscitation CPR Disease Models, Animal Emergency Emergency medical care Erythropoietin - therapeutic use Female Free radicals Heart Arrest - drug therapy Heart Arrest - etiology Hogs Sodium chloride Survival Swine Treatment Outcome Ventilators Ventricular Fibrillation - complications |
| title | Erythropoietin administration facilitates return of spontaneous circulation and improves survival in a pig model of cardiac arrest |
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