The influence of osteoprotegerin genetic polymorphisms on bone mineral density and osteoporosis in Chinese postmenopausal women
Previous studies suggest that the osteoprotegerin gene (OPG) plays an important role in the development of osteoporosis. This study aims to investigate the potential association between OPG genetic polymorphisms and bone mineral density (BMD) and osteoporosis in postmenopausal women. 938 Chinese pos...
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| Veröffentlicht in: | International immunopharmacology 2014-09, Vol.22 (1), p.200-203 |
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| creator | Sun, Tao Chen, Mingqi Lin, Xiaoyan Yu, Ruixiang Zhao, Yong Wang, Jianhang |
| description | Previous studies suggest that the osteoprotegerin gene (OPG) plays an important role in the development of osteoporosis. This study aims to investigate the potential association between OPG genetic polymorphisms and bone mineral density (BMD) and osteoporosis in postmenopausal women. 938 Chinese postmenopausal women were enrolled. The lumbar spine (L2–4) BMD, neck BMD, and total hip BMD were measured by dual energy X-ray absorptiometry (DEXA). The genotypes of OPG genetic polymorphisms were evaluated by the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing methods. Our data indicated that subjects with genotype TT of the g.26395T>C genetic polymorphism showed a significantly higher adjusted value of BMD when compared with those of genotypes TC and CC. Subjects with genotype AA of the g.27649A>G genetic polymorphism showed a significantly higher adjusted value of BMD than those of genotypes AG and GG. These findings suggest that the OPG genetic polymorphisms may affect BMD and osteoporosis in Chinese postmenopausal women.
•Osteoprotegerin gene (OPG) plays an important role in the development of osteoporosis.•The g.26395T>C and g.27649A>G genetic polymorphisms were associated with lumbar spine, neck hip and total hip BMD.•The OPG gene contributes to BMD and osteoporosis in Chinese postmenopausal women. |
| doi_str_mv | 10.1016/j.intimp.2014.06.023 |
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•Osteoprotegerin gene (OPG) plays an important role in the development of osteoporosis.•The g.26395T>C and g.27649A>G genetic polymorphisms were associated with lumbar spine, neck hip and total hip BMD.•The OPG gene contributes to BMD and osteoporosis in Chinese postmenopausal women.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2014.06.023</identifier><identifier>PMID: 24975835</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Bone Density - genetics ; Bone mineral density ; China ; DNA Mutational Analysis ; Female ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Hip - diagnostic imaging ; Hip - pathology ; Humans ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - pathology ; Middle Aged ; Neck - diagnostic imaging ; Neck - pathology ; Osteoporosis ; Osteoporosis, Postmenopausal - genetics ; Osteoprotegerin - genetics ; Osteoprotegerin gene ; Polymorphism, Genetic ; Postmenopausal women ; Radiography</subject><ispartof>International immunopharmacology, 2014-09, Vol.22 (1), p.200-203</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-b834b8651f59810c2a98cad1fb2a3438f6017ef390637cb8ea08c67acc9647ae3</citedby><cites>FETCH-LOGICAL-c362t-b834b8651f59810c2a98cad1fb2a3438f6017ef390637cb8ea08c67acc9647ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2014.06.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24975835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Chen, Mingqi</creatorcontrib><creatorcontrib>Lin, Xiaoyan</creatorcontrib><creatorcontrib>Yu, Ruixiang</creatorcontrib><creatorcontrib>Zhao, Yong</creatorcontrib><creatorcontrib>Wang, Jianhang</creatorcontrib><title>The influence of osteoprotegerin genetic polymorphisms on bone mineral density and osteoporosis in Chinese postmenopausal women</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Previous studies suggest that the osteoprotegerin gene (OPG) plays an important role in the development of osteoporosis. This study aims to investigate the potential association between OPG genetic polymorphisms and bone mineral density (BMD) and osteoporosis in postmenopausal women. 938 Chinese postmenopausal women were enrolled. The lumbar spine (L2–4) BMD, neck BMD, and total hip BMD were measured by dual energy X-ray absorptiometry (DEXA). The genotypes of OPG genetic polymorphisms were evaluated by the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing methods. Our data indicated that subjects with genotype TT of the g.26395T>C genetic polymorphism showed a significantly higher adjusted value of BMD when compared with those of genotypes TC and CC. Subjects with genotype AA of the g.27649A>G genetic polymorphism showed a significantly higher adjusted value of BMD than those of genotypes AG and GG. These findings suggest that the OPG genetic polymorphisms may affect BMD and osteoporosis in Chinese postmenopausal women.
•Osteoprotegerin gene (OPG) plays an important role in the development of osteoporosis.•The g.26395T>C and g.27649A>G genetic polymorphisms were associated with lumbar spine, neck hip and total hip BMD.•The OPG gene contributes to BMD and osteoporosis in Chinese postmenopausal women.</description><subject>Aged</subject><subject>Bone Density - genetics</subject><subject>Bone mineral density</subject><subject>China</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hip - diagnostic imaging</subject><subject>Hip - pathology</subject><subject>Humans</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Middle Aged</subject><subject>Neck - diagnostic imaging</subject><subject>Neck - pathology</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - genetics</subject><subject>Osteoprotegerin - genetics</subject><subject>Osteoprotegerin gene</subject><subject>Polymorphism, Genetic</subject><subject>Postmenopausal women</subject><subject>Radiography</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAUhUVoSNIkbxCKlt3YkSzrx5tCGZq0EMgmWQtZvs5osCVXkltmlVevhpl22dXVFeecy_kQuqOkpoSK-13tfHbzUjeEtjURNWnYGbqiSqqKSsI_lDcXsuJSdJfoY0o7Qsp_Sy_QZdN2kivGr9D7yxaw8-O0greAw4hDyhCWGDK8QXQev4GH7CxewrSfQ1y2Ls0JB4_74AHPzkM0Ex7AJ5f32PjhlBBiSC6VbLzZFlGCkpDyDD4sZk3F8juU5Qadj2ZKcHua1-j14dvL5nv19Pz4Y_P1qbJMNLnqFWt7JTgdeacosY3plDUDHfvGsJapUZRuMLKOCCZtr8AQZYU01nailQbYNfp8zC3Nfq6Qsp5dsjBNxkNYk6acU9IQ2agibY9SWxqkCKNeoptN3GtK9AG93ukjen1Ar4nQBX2xfTpdWPsZhn-mv6yL4MtRAKXnLwdRJ-sO1AcXwWY9BPf_C38AdnSavw</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Sun, Tao</creator><creator>Chen, Mingqi</creator><creator>Lin, Xiaoyan</creator><creator>Yu, Ruixiang</creator><creator>Zhao, Yong</creator><creator>Wang, Jianhang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>The influence of osteoprotegerin genetic polymorphisms on bone mineral density and osteoporosis in Chinese postmenopausal women</title><author>Sun, Tao ; Chen, Mingqi ; Lin, Xiaoyan ; Yu, Ruixiang ; Zhao, Yong ; Wang, Jianhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-b834b8651f59810c2a98cad1fb2a3438f6017ef390637cb8ea08c67acc9647ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Bone Density - genetics</topic><topic>Bone mineral density</topic><topic>China</topic><topic>DNA Mutational Analysis</topic><topic>Female</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hip - diagnostic imaging</topic><topic>Hip - pathology</topic><topic>Humans</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Middle Aged</topic><topic>Neck - diagnostic imaging</topic><topic>Neck - pathology</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - genetics</topic><topic>Osteoprotegerin - genetics</topic><topic>Osteoprotegerin gene</topic><topic>Polymorphism, Genetic</topic><topic>Postmenopausal women</topic><topic>Radiography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Chen, Mingqi</creatorcontrib><creatorcontrib>Lin, Xiaoyan</creatorcontrib><creatorcontrib>Yu, Ruixiang</creatorcontrib><creatorcontrib>Zhao, Yong</creatorcontrib><creatorcontrib>Wang, Jianhang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Tao</au><au>Chen, Mingqi</au><au>Lin, Xiaoyan</au><au>Yu, Ruixiang</au><au>Zhao, Yong</au><au>Wang, Jianhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of osteoprotegerin genetic polymorphisms on bone mineral density and osteoporosis in Chinese postmenopausal women</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>22</volume><issue>1</issue><spage>200</spage><epage>203</epage><pages>200-203</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Previous studies suggest that the osteoprotegerin gene (OPG) plays an important role in the development of osteoporosis. This study aims to investigate the potential association between OPG genetic polymorphisms and bone mineral density (BMD) and osteoporosis in postmenopausal women. 938 Chinese postmenopausal women were enrolled. The lumbar spine (L2–4) BMD, neck BMD, and total hip BMD were measured by dual energy X-ray absorptiometry (DEXA). The genotypes of OPG genetic polymorphisms were evaluated by the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing methods. Our data indicated that subjects with genotype TT of the g.26395T>C genetic polymorphism showed a significantly higher adjusted value of BMD when compared with those of genotypes TC and CC. Subjects with genotype AA of the g.27649A>G genetic polymorphism showed a significantly higher adjusted value of BMD than those of genotypes AG and GG. These findings suggest that the OPG genetic polymorphisms may affect BMD and osteoporosis in Chinese postmenopausal women.
•Osteoprotegerin gene (OPG) plays an important role in the development of osteoporosis.•The g.26395T>C and g.27649A>G genetic polymorphisms were associated with lumbar spine, neck hip and total hip BMD.•The OPG gene contributes to BMD and osteoporosis in Chinese postmenopausal women.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24975835</pmid><doi>10.1016/j.intimp.2014.06.023</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Bone Density - genetics Bone mineral density China DNA Mutational Analysis Female Genetic polymorphisms Genetic Predisposition to Disease Genotype Hip - diagnostic imaging Hip - pathology Humans Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Middle Aged Neck - diagnostic imaging Neck - pathology Osteoporosis Osteoporosis, Postmenopausal - genetics Osteoprotegerin - genetics Osteoprotegerin gene Polymorphism, Genetic Postmenopausal women Radiography |
| title | The influence of osteoprotegerin genetic polymorphisms on bone mineral density and osteoporosis in Chinese postmenopausal women |
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