Comparison Between Intravenous and Intra-articular Regimens of Tranexamic Acid in Reducing Blood Loss During Total Knee Arthroplasty
Abstract Tranexamic acid is an antifibrinolytic drug used widely to prevent bleeding. Its use in reducing bleeding during total knee arthroplasty surgery is well proven but there is no final consensus regarding the regimen. The purpose of our study was to compare the effectiveness of intravenous and...
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| Veröffentlicht in: | The Journal of arthroplasty 2014-08, Vol.29 (8), p.1525-1527 |
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| container_title | The Journal of arthroplasty |
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| creator | Soni, Ashwani, MS Saini, Raghav, MS Gulati, Anmol, MS Paul, Rajesh, MS Bhatty, Shiraj, MS Rajoli, Sreekanth Reddy, MS |
| description | Abstract Tranexamic acid is an antifibrinolytic drug used widely to prevent bleeding. Its use in reducing bleeding during total knee arthroplasty surgery is well proven but there is no final consensus regarding the regimen. The purpose of our study was to compare the effectiveness of intravenous and intra-articular regimen of tranexamic acid during the total knee arthroplasty surgery. A total of 40 patients were received three doses of intravenous tranexamic acid during total knee arthroplasty surgery. Intra-articular tranexamic acid was used in 40 patients during the surgery. We concluded that intra-articular tranexamic acid is equally effective as three dose intravenous regimen in reducing blood loss during total knee arthroplasty surgery. |
| doi_str_mv | 10.1016/j.arth.2014.03.039 |
| format | Article |
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Its use in reducing bleeding during total knee arthroplasty surgery is well proven but there is no final consensus regarding the regimen. The purpose of our study was to compare the effectiveness of intravenous and intra-articular regimen of tranexamic acid during the total knee arthroplasty surgery. A total of 40 patients were received three doses of intravenous tranexamic acid during total knee arthroplasty surgery. Intra-articular tranexamic acid was used in 40 patients during the surgery. We concluded that intra-articular tranexamic acid is equally effective as three dose intravenous regimen in reducing blood loss during total knee arthroplasty surgery.</description><identifier>ISSN: 0883-5403</identifier><identifier>EISSN: 1532-8406</identifier><identifier>DOI: 10.1016/j.arth.2014.03.039</identifier><identifier>PMID: 24814890</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; antifibrinolytic ; Antifibrinolytic Agents - administration & dosage ; Arthroplasty, Replacement, Knee - adverse effects ; blood loss ; Blood Loss, Surgical - prevention & control ; Blood Transfusion ; Female ; Hemoglobins - metabolism ; Humans ; Injections, Intra-Articular ; Injections, Intravenous ; Male ; Middle Aged ; Orthopedics ; Postoperative Hemorrhage - prevention & control ; total knee arthroplasty ; tranexamic acid ; Tranexamic Acid - administration & dosage</subject><ispartof>The Journal of arthroplasty, 2014-08, Vol.29 (8), p.1525-1527</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. 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Its use in reducing bleeding during total knee arthroplasty surgery is well proven but there is no final consensus regarding the regimen. The purpose of our study was to compare the effectiveness of intravenous and intra-articular regimen of tranexamic acid during the total knee arthroplasty surgery. A total of 40 patients were received three doses of intravenous tranexamic acid during total knee arthroplasty surgery. Intra-articular tranexamic acid was used in 40 patients during the surgery. We concluded that intra-articular tranexamic acid is equally effective as three dose intravenous regimen in reducing blood loss during total knee arthroplasty surgery.</description><subject>Aged</subject><subject>antifibrinolytic</subject><subject>Antifibrinolytic Agents - administration & dosage</subject><subject>Arthroplasty, Replacement, Knee - adverse effects</subject><subject>blood loss</subject><subject>Blood Loss, Surgical - prevention & control</subject><subject>Blood Transfusion</subject><subject>Female</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Injections, Intra-Articular</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Postoperative Hemorrhage - prevention & control</subject><subject>total knee arthroplasty</subject><subject>tranexamic acid</subject><subject>Tranexamic Acid - administration & dosage</subject><issn>0883-5403</issn><issn>1532-8406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuKFDEUhoMoTjv6Ai4kSzfVnlzqBiL0tLfBBkHbdUglp8a0VUmbVI323gc3RY8uXAgHQpL_XP7vEPKUwZoBq14c1jpOX9ccmFyDyNHeIytWCl40Eqr7ZAVNI4pSgrggj1I6ADBWlvIhueCyYbJpYUV-bcN41NGl4OkVTj8QPb32U9S36MOcqPb2fC9yL2fmQUf6CW_ciD7R0NN91B5_6tEZujHOUufzt52N8zf0agjB0l1Iib6e4_KyD5Me6AePSDd59BiOg07T6TF50Osh4ZO785J8eftmv31f7D6-u95udoXJ805F2_GamabnthNtJyqenaHhFeOdBll3suxMxUrbdliVIDVAK1HWNdqyr0AIcUmen-seY_g-Y5rU6JLBYcgeslmV6WSwbcurLOVnqYl5_oi9OkY36nhSDNRCXx3UQl8t9BWIHG1OenZXf-5GtH9T_uDOgpdnAWaXtw6jSsahN2hdRDMpG9z_67_6J90Mzjujh294wnQIc_SZn2IqcQXq87L_Zf1MAnBe1-I3VdarzA</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Soni, Ashwani, MS</creator><creator>Saini, Raghav, MS</creator><creator>Gulati, Anmol, MS</creator><creator>Paul, Rajesh, MS</creator><creator>Bhatty, Shiraj, MS</creator><creator>Rajoli, Sreekanth Reddy, MS</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Comparison Between Intravenous and Intra-articular Regimens of Tranexamic Acid in Reducing Blood Loss During Total Knee Arthroplasty</title><author>Soni, Ashwani, MS ; 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| ispartof | The Journal of arthroplasty, 2014-08, Vol.29 (8), p.1525-1527 |
| issn | 0883-5403 1532-8406 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Aged antifibrinolytic Antifibrinolytic Agents - administration & dosage Arthroplasty, Replacement, Knee - adverse effects blood loss Blood Loss, Surgical - prevention & control Blood Transfusion Female Hemoglobins - metabolism Humans Injections, Intra-Articular Injections, Intravenous Male Middle Aged Orthopedics Postoperative Hemorrhage - prevention & control total knee arthroplasty tranexamic acid Tranexamic Acid - administration & dosage |
| title | Comparison Between Intravenous and Intra-articular Regimens of Tranexamic Acid in Reducing Blood Loss During Total Knee Arthroplasty |
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