Chromatin modifications remodel cardiac gene expression

Signalling and transcriptional control involve precise programmes of gene activation and suppression necessary for cardiovascular physiology. Deep sequencing of DNA-bound transcription factors reveals a remarkable complexity of co-activators or co-repressors that serve to alter chromatin modificatio...

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Veröffentlicht in:	Cardiovascular research 2014-07, Vol.103 (1), p.7-16
Hauptverfasser:	Mathiyalagan, Prabhu, Keating, Samuel T, Du, Xiao-Jun, El-Osta, Assam
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cardiomegaly - genetics Cardiomegaly - metabolism Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly Enhancer of Zeste Homolog 2 Protein Gene Expression Regulation Heart Failure - drug therapy Heart Failure - genetics Heart Failure - metabolism Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Humans Methylation Mice Mice, Knockout Models, Cardiovascular Myocardium - metabolism Polycomb Repressive Complex 2 - deficiency Polycomb Repressive Complex 2 - genetics Protein Processing, Post-Translational Signal Transduction
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