A Controlled Trial of Amantadine and Rimantadine in the Prophylaxis of Influenza a Infection

Four hundred fifty volunteers participated in a placebo-controlled, double-blind, randomized trial of the prophylactic effects of rimantadine and amantadine during an outbreak of influenza A. The subjects received drugs orally at a dose of 100 mg twice a day for six weeks. Influenza-like illness occ...

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Veröffentlicht in:	The New England journal of medicine 1982-09, Vol.307 (10), p.580-584
Hauptverfasser:	Dolin, Raphael, Reichman, Richard C, Madore, H. Paul, Maynard, Raina, Linton, Pamela N, Webber-Jones, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adolescent Adult Amantadine Amantadine - adverse effects Amantadine - therapeutic use Antimicrobial agents Chemotherapy Clinical Trials as Topic Disease prevention Enzymes Family medical history Health surveillance Humans Illnesses Immunoglobulins Infant, Newborn Infections Infectious diseases Influenza Influenza A influenza A virus Influenza A virus - isolation & purification Influenza, Human - epidemiology Influenza, Human - prevention & control Laboratory animals Middle Aged Outbreaks Patient Compliance Prophylaxis Random Allocation Respiratory diseases Rimantadine - adverse effects Rimantadine - therapeutic use Viruses Volunteers
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Zusammenfassung:	Four hundred fifty volunteers participated in a placebo-controlled, double-blind, randomized trial of the prophylactic effects of rimantadine and amantadine during an outbreak of influenza A. The subjects received drugs orally at a dose of 100 mg twice a day for six weeks. Influenza-like illness occurred in 41 per cent of the subjects receiving placebo but in only 14 per cent of those receiving rimantadine and 9 per cent of those receiving amantadine (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198209023071002