Depletion of Penicillin G Residues in Heavy Sows after Intramuscular Injection. Part I: Tissue Residue Depletion
Heavy sows (n = 126) were treated with penicillin G procaine at a 5× label dose (33 000 IU/kg) for 3 consecutive days by intramuscular (IM) injection using three patterns of drug administration. Treatments differed by injection pattern and injection volume. Sets of sows were slaughtered 5, 10, 15, 2...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2014-07, Vol.62 (30), p.7577-7585 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Lupton, S. J Shelver, W. L Newman, D. J Larsen, S Smith, D. J |
| description | Heavy sows (n = 126) were treated with penicillin G procaine at a 5× label dose (33 000 IU/kg) for 3 consecutive days by intramuscular (IM) injection using three patterns of drug administration. Treatments differed by injection pattern and injection volume. Sets of sows were slaughtered 5, 10, 15, 20, 25, 32, and 39 days after the last treatment; skeletal muscle, kidney, serum, and urine were collected for penicillin G analysis by LC–MS/MS. Penicillin G at withdrawal day 5 averaged 23.5 ± 10.5 and 3762 ± 1932 ng/g in muscle and kidney, respectively. After 15 days of withdrawal, muscle penicillin G residues were quantifiable in only one treated hog (3.4 ng/g) but averaged 119 ± 199 ng/g in kidneys. Using a hypothetical tolerance of 50 ng/g and a natural log–linear depletion model, the withdrawal period required for penicillin depletion to 50 ng/g was 11 days for skeletal muscle and 47 days for kidney. |
| doi_str_mv | 10.1021/jf501492v |
| format | Article |
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After 15 days of withdrawal, muscle penicillin G residues were quantifiable in only one treated hog (3.4 ng/g) but averaged 119 ± 199 ng/g in kidneys. Using a hypothetical tolerance of 50 ng/g and a natural log–linear depletion model, the withdrawal period required for penicillin depletion to 50 ng/g was 11 days for skeletal muscle and 47 days for kidney.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf501492v</identifier><identifier>PMID: 25025185</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Chromatography, High Pressure Liquid - veterinary ; Chromatography, Liquid - veterinary ; Drug Residues - analysis ; Drug Residues - pharmacokinetics ; Female ; Injections, Intramuscular ; Kidney - drug effects ; Kidney - metabolism ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Penicillin G Procaine - administration & dosage ; Penicillin G Procaine - pharmacokinetics ; Swine ; Tandem Mass Spectrometry - veterinary</subject><ispartof>Journal of agricultural and food chemistry, 2014-07, Vol.62 (30), p.7577-7585</ispartof><rights>Copyright © 2014 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a315t-eb64be7c9c1f317e7e23fdcab9b7882dc73f49c42a0b08e86a172e7b714c78c93</citedby><cites>FETCH-LOGICAL-a315t-eb64be7c9c1f317e7e23fdcab9b7882dc73f49c42a0b08e86a172e7b714c78c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf501492v$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf501492v$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25025185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lupton, S. J</creatorcontrib><creatorcontrib>Shelver, W. L</creatorcontrib><creatorcontrib>Newman, D. J</creatorcontrib><creatorcontrib>Larsen, S</creatorcontrib><creatorcontrib>Smith, D. J</creatorcontrib><title>Depletion of Penicillin G Residues in Heavy Sows after Intramuscular Injection. Part I: Tissue Residue Depletion</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Heavy sows (n = 126) were treated with penicillin G procaine at a 5× label dose (33 000 IU/kg) for 3 consecutive days by intramuscular (IM) injection using three patterns of drug administration. Treatments differed by injection pattern and injection volume. Sets of sows were slaughtered 5, 10, 15, 20, 25, 32, and 39 days after the last treatment; skeletal muscle, kidney, serum, and urine were collected for penicillin G analysis by LC–MS/MS. Penicillin G at withdrawal day 5 averaged 23.5 ± 10.5 and 3762 ± 1932 ng/g in muscle and kidney, respectively. After 15 days of withdrawal, muscle penicillin G residues were quantifiable in only one treated hog (3.4 ng/g) but averaged 119 ± 199 ng/g in kidneys. Using a hypothetical tolerance of 50 ng/g and a natural log–linear depletion model, the withdrawal period required for penicillin depletion to 50 ng/g was 11 days for skeletal muscle and 47 days for kidney.</description><subject>Animals</subject><subject>Chromatography, High Pressure Liquid - veterinary</subject><subject>Chromatography, Liquid - veterinary</subject><subject>Drug Residues - analysis</subject><subject>Drug Residues - pharmacokinetics</subject><subject>Female</subject><subject>Injections, Intramuscular</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Penicillin G Procaine - administration & dosage</subject><subject>Penicillin G Procaine - pharmacokinetics</subject><subject>Swine</subject><subject>Tandem Mass Spectrometry - veterinary</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQhoMotlYP_gHJRdDD1iS7abLepGpbKFi0npdsdgJZ9stkt9J_75Z-nDwNL_PwDPMidEvJmBJGn3LDCY1itjlDQ8oZCTil8hwNSb8MJJ_QAbryPieESC7IJRowThinkg9R8wpNAa2tK1wbvILKalsUtsIz_AneZh143Kc5qM0Wf9W_HivTgsOLqnWq7LzuCrVLOeidZIxXyrV48YzX1vsOjhJ8OnONLowqPNwc5gh9v7-tp_Ng-TFbTF-WgQopbwNIJ1EKQseampAKEMBCk2mVxqmQkmVahCaKdcQUSYkEOVFUMBCpoJEWUsfhCD3svY2rf_ov2qS0XkNRqArqzieUc0KE5DLs0cc9ql3tvQOTNM6Wym0TSpJdwcmp4J69O2i7tITsRB4b7YH7PaC0T_K6c1X_5T-iP1nqgnU</recordid><startdate>20140730</startdate><enddate>20140730</enddate><creator>Lupton, S. 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J</creatorcontrib><creatorcontrib>Shelver, W. L</creatorcontrib><creatorcontrib>Newman, D. J</creatorcontrib><creatorcontrib>Larsen, S</creatorcontrib><creatorcontrib>Smith, D. J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lupton, S. J</au><au>Shelver, W. L</au><au>Newman, D. J</au><au>Larsen, S</au><au>Smith, D. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depletion of Penicillin G Residues in Heavy Sows after Intramuscular Injection. Part I: Tissue Residue Depletion</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2014-07-30</date><risdate>2014</risdate><volume>62</volume><issue>30</issue><spage>7577</spage><epage>7585</epage><pages>7577-7585</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Heavy sows (n = 126) were treated with penicillin G procaine at a 5× label dose (33 000 IU/kg) for 3 consecutive days by intramuscular (IM) injection using three patterns of drug administration. Treatments differed by injection pattern and injection volume. Sets of sows were slaughtered 5, 10, 15, 20, 25, 32, and 39 days after the last treatment; skeletal muscle, kidney, serum, and urine were collected for penicillin G analysis by LC–MS/MS. Penicillin G at withdrawal day 5 averaged 23.5 ± 10.5 and 3762 ± 1932 ng/g in muscle and kidney, respectively. After 15 days of withdrawal, muscle penicillin G residues were quantifiable in only one treated hog (3.4 ng/g) but averaged 119 ± 199 ng/g in kidneys. Using a hypothetical tolerance of 50 ng/g and a natural log–linear depletion model, the withdrawal period required for penicillin depletion to 50 ng/g was 11 days for skeletal muscle and 47 days for kidney.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>25025185</pmid><doi>10.1021/jf501492v</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Chromatography, High Pressure Liquid - veterinary Chromatography, Liquid - veterinary Drug Residues - analysis Drug Residues - pharmacokinetics Female Injections, Intramuscular Kidney - drug effects Kidney - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Penicillin G Procaine - administration & dosage Penicillin G Procaine - pharmacokinetics Swine Tandem Mass Spectrometry - veterinary |
| title | Depletion of Penicillin G Residues in Heavy Sows after Intramuscular Injection. Part I: Tissue Residue Depletion |
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